Mohácsi G, Magori A, Sonkodi S
First Department of Internal Medicine, Szeged University Medical School, Hungary.
Int Urol Nephrol. 1988;20(3):315-25. doi: 10.1007/BF02549523.
The clinical course of 30 patients with idiopathic membranous glomerulonephritis has been followed up for 8.1 +/- 3.4 (4-17) years. First, in each case a long-term prednisone treatment was administered. During this therapy 12 (40%) patients improved and 9 had remission. In the 18 (60%) steroid resistant cases the treatment was combined with cytostatic drugs. After a combined regime for 1.9 +/- 0.8 years, 8 patients have improved, 2 of whom remitted. It has been suggested that due to a long-term immunomodulator therapy the level of urinary protein excretion might be reduced in 77% of patients. There was no effect of the applied treatment in 7% of cases, still in 16% a gradual deterioration was observed. Relapsing nephrotic syndrome has occurred in 3 (10%) of the total cases. Side effects requiring cessation of treatment were not observed.
对30例特发性膜性肾小球肾炎患者的临床病程进行了8.1±3.4（4 - 17）年的随访。首先，对每例患者均给予长期泼尼松治疗。在此治疗期间，12例（40%）患者病情改善，9例缓解。在18例（60%）激素抵抗病例中，治疗联合了细胞毒性药物。联合治疗1.9±0.8年后，8例患者病情改善，其中2例缓解。有人提出，由于长期免疫调节剂治疗，77%的患者尿蛋白排泄水平可能降低。7%的病例应用治疗无效，仍有16%观察到病情逐渐恶化。3例（10%）总病例出现复发性肾病综合征。未观察到需要停止治疗的副作用。
