Shi Xiu-Xiu, Xu Wang-Li, Qin Jiang, Sun Hai-Yan, Hu Yuan, Tang Jin-Shu, Wu Jin-Ling, Zhu Jia-Liang, Hou Shu-Xun, Wu Xin-Bao, Zhoumou Wang, Wang Ning-Hua, Xie Yu-Xiao, Zhao Hui, Gu Xin, Lu Ming, Li Da-Wei
The Fourth Medical Center of PLAGeneral Hospital, Beijing 100048, China.
Zhongguo Gu Shang. 2021 May 25;34(5):406-16. doi: 10.12200/j.issn.1003-0034.2021.05.004.
To compare clinical effects of different postoperative rehabilitation modes on lumbar degenerative diseases, and explore influence of rehabilitation mode and other factors on postoperative effect.
From June 2013 to July 2016, totally 900 patients were admitted from nine tertiary hospitals in Beijing to perform single segment bone grafting and internal fixation due to lumbar degenerative diseases were prospectively analyzed. There were 428 males and 472 females, the age of patient over 18 years old, with an average of (51.42±12.41) years old;according to patients' subjective wishes and actual residence conditions, all patients were divided into three groups, named as observation group 1 (performed integrated rehabilitation approach and orthopedic treatment model intervention), observation group 2 (performed integrated rehabilitation approach and orthopedic treatment, classified rehabilitation model intervention), and control group(performed routine rehabilitation model intervention). Visual analogue scale(VAS), Oswestry Disability Index(ODI) and Japanese Orthopaedic Association (JOA) were used to evaluate postoperative efficacy among three groups at 24 weeks. Possible factors affecting the postoperative efficacy including age, age grouping, gender, body mass index (BMI), BMI grouping, education level, visiting hospital, payment method of medical expenses, preoperative complications, preoperative JOA score, clinical diagnosis, surgery section, operative method, intraoperative bleeding volume, postoperative complications and rehabilitation mode were listed as independent variables, and postoperative ODI score at 24 weeks as dependent variables. Univariate analysis was used to analyze relationship between influencing factors and postoperative efficacy. Multiple linear regression was used to analyze relationship between influencing factors, rehabilitation mode and postoperative ODI score at 24 weeks, in further to find out the main reasons which affect postoperative efficacy, and to analyze impact of rehabilitation mode on postoperative efficacy.
All patients were followed up for 24 weeks after operation. All incisions healed at stage I with stable internal fixation. (1)Evaluation of postoperative efficacy:① There were no statistical differences in preoperative VAS and ODI among three groups(>0.05), the degree of pain and dysfunction decreased among three groups after operation, and had differences in postoperative VAS and ODI among three groups (<0.05). There were no significant differences between observation group 1 and observation group 2(>0.05); while compared with observation group 1 and control group, observation group 2 and control group, there were significant differences (<0.05). ②The function among three groups were improved in varying degrees after operation. There was difference in JOA score among three groups before operation and 24 weeks after operation (<0.05). There were no difference in JOA score among three groups between observation group 1 and observation group 2 (>0.05);while compared with observation group 1 and control group, observation group 2 and control group, there were significant differences (<0.05). (2)Influencing factors at 24 weeks after operation:①Univariate analysis showed gender, age, age grouping, education level, preoperative complications, clinical diagnosis, operative section, operative method, preoperative JOA score and rehabilitation mode had statistical significance with postoperative ODI score at 24 weeks (<0.05). BMI, BMI grouping, payment method of medical expenses, visiting hospital, intraoperative bleeding volume, postoperative complications had no statistical significance with postoperative ODI score at 24 weeks (<0.05).②Multivariate analysis results showed gender, rehabilitation mode, age, preoperative JOA score entered the equation eventually, stepwise multiple linear equation obtained had statistical significance (=12.294, = 0.000). Among rehabilitation mode, standardized regression coefficient of the integrated rehabilitation approach and orthopedic treatment with classified rehabilitation model was absolute value of the largest (0.176), which had the greatest influence on postoperative curative effect. The degree of dysfunction in control group was higher than that in observation group 1 and observation group 2. Postoperative dysfunction was more severe in males than that of in females. Older age has higher degree of dysfunction after operation. Lower preoperative JOA score has higher degree of dysfunction after operation.
Preoperative JOA score, gender, age could predict postoperative clinical effects of lumbar degenerative diseases in varying degrees treated with single level bone graft fusion and internal fixation. Different rehabilitation modes could improve clinical effects. Intergrated rehabilitation orthopedic treatment model and integrated rehabilitation approach and orthopedic treatment with classifiedrehabilitation model are superior to conventional rehabilitation model in improving patients' postoperative function and relieving pain, which is worthy of promoting in clinical.
比较不同术后康复模式对腰椎退行性疾病的临床效果,探讨康复模式及其他因素对术后效果的影响。
前瞻性分析2013年6月至2016年7月期间北京9家三级医院收治的900例因腰椎退行性疾病行单节段植骨内固定术的患者。其中男性428例,女性472例,患者年龄均超过18岁,平均年龄为(51.42±12.41)岁;根据患者主观意愿及实际居住情况,将所有患者分为三组,分别为观察组1(采用综合康复方法及骨科治疗模式干预)、观察组2(采用综合康复方法及骨科治疗,分类康复模式干预)和对照组(采用常规康复模式干预)。采用视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)和日本矫形外科学会(JOA)评分在术后24周评估三组患者的疗效。将可能影响术后疗效的因素包括年龄、年龄分组、性别、体重指数(BMI)、BMI分组、教育程度、就诊医院、医疗费用支付方式、术前并发症、术前JOA评分、临床诊断、手术节段、手术方式、术中出血量、术后并发症及康复模式作为自变量,将术后24周的ODI评分作为因变量。采用单因素分析影响因素与术后疗效的关系。采用多元线性回归分析影响因素、康复模式与术后24周ODI评分的关系,进一步找出影响术后疗效的主要原因,并分析康复模式对术后疗效的影响。
所有患者术后均随访24周。所有切口均Ⅰ期愈合,内固定稳定。(1)术后疗效评价:①三组术前VAS和ODI差异无统计学意义(>0.05),术后三组疼痛程度和功能障碍程度均减轻,术后三组VAS和ODI差异有统计学意义(<0.05)。观察组1与观察组2之间差异无统计学意义(>0.05);而观察组1与对照组、观察组2与对照组比较,差异有统计学意义(<0.05)。②术后三组功能均有不同程度改善。术前与术后24周三组JOA评分差异有统计学意义(<0.05)。观察组1与观察组2之间JOA评分差异无统计学意义(>0.05);而观察组1与对照组、观察组2与对照组比较,差异有统计学意义(<0.05)。(2)术后24周影响因素:①单因素分析显示性别、年龄、年龄分组、教育程度、术前并发症、临床诊断、手术节段、手术方式、术前JOA评分及康复模式与术后24周ODI评分有统计学意义(<0.05)。BMI、BMI分组、医疗费用支付方式、就诊医院、术中出血量、术后并发症与术后24周ODI评分无统计学意义(<0.05)。②多因素分析结果显示性别、康复模式、年龄、术前JOA评分最终进入方程,得到的逐步多元线性方程有统计学意义(=12.294,=0.000)。在康复模式中,综合康复方法及骨科治疗与分类康复模式的标准化回归系数绝对值最大(0.176),对术后疗效影响最大。对照组功能障碍程度高于观察组1和观察组2。术后男性功能障碍程度高于女性。年龄越大术后功能障碍程度越高。术前JOA评分越低术后功能障碍程度越高。
术前JOA评分、性别、年龄可不同程度预测单节段植骨融合内固定治疗腰椎退行性疾病的术后临床效果。不同康复模式可改善临床效果。综合康复骨科治疗模式及综合康复方法及骨科治疗与分类康复模式在改善患者术后功能及缓解疼痛方面优于传统康复模式,值得临床推广。