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紧凑型电离室的结构和灵敏体积对磁场相关剂量响应的作用。

The role of the construction and sensitive volume of compact ionization chambers on the magnetic field-dependent dose response.

机构信息

University Clinic for Medical Radiation Physics, Medical Campus Pius Hospital, Carl von Ossietzky University, Oldenburg, Germany.

PTW Freiburg, Freiburg, Germany.

出版信息

Med Phys. 2021 Aug;48(8):4572-4585. doi: 10.1002/mp.14994. Epub 2021 Jul 11.

Abstract

PURPOSE

The magnetic-field correction factors of compact air-filled ionization chambers have been investigated experimentally and using Monte Carlo simulations up to 1.5 T. The role of the nonsensitive region within the air cavity and influence of the chamber construction on its dose response have been elucidated.

MATERIALS AND METHODS

The PTW Semiflex 3D 31021, PinPoint 3D 31022, and Sun Nuclear Cooperation SNC125c chambers were studied. The factors were measured at the experimental facility of the German National Metrology Institute (PTB) up to 1.4 T using a 6 MV photon beam. The chambers were positioned with the chamber axis perpendicular to the beam axis (radial); and parallel to the beam axis (axial). In both cases, the magnetic field was directed perpendicular to both the beam axis and chamber axis. Additionally, the sensitive volumes of these chambers have been experimentally determined using a focused proton microbeam and finite element method. Beside the simulations of factors, detailed Monte Carlo technique has been applied to analyse the secondary electron fluence within the air cavity, that is, the number of secondary electrons and the average path length as a function of the magnetic field strength.

RESULTS

A nonsensitive volume within the air cavity adjacent to the chamber stem for the PTW chambers has been identified from the microbeam measurements and FEM calculations. The dose response of the three investigated ionization chambers does not deviate by more than 4% from the field-free case within the range of magnetic fields studied in this work for both the radial and axial orientations. The simulated for the fully guarded PTW chambers deviate by up to 6% if their sensitive volumes are not correctly considered during the simulations. After the implementation of the sensitive volume derived from the microbeam measurements, an agreement of better than 1% between the experimental and Monte Carlo factors for all three chambers can be achieved. Detailed analysis reveals that the stem of the PTW chambers could give rise to a shielding effect reducing the number of secondary electrons entering the air cavity in the presence of magnetic field. However, the magnetic field dependence of their path length within the air cavity is shown to be weaker than for the SNC125c chamber, where the length of the air cavity is larger than its diameter. For this chamber it is shown that the number of electrons and their path lengths in the cavity depend stronger on the magnetic field.

DISCUSSION AND CONCLUSION

For clinical measurements up to 1.5 T, the required corrections of the three chambers could be kept within 3% in both the investigated chamber orientations. The results reiterate the importance of considering the sensitive volume of fully guarded chambers, even for the investigated compact chambers, in the Monte Carlo simulations of chamber response in magnetic field. The resulting magnetic field-dependent dose response has been demonstrated to depend on the chamber construction, such as the ratio between length and the diameter of the air cavity as well as the design of the chamber stem.

摘要

目的

本研究通过实验和蒙特卡罗模拟,对紧凑型空气填充电离室的磁场校正因子进行了研究,测量范围为 1.5T。本研究阐明了空气腔非灵敏区的作用以及电离室结构对其剂量响应的影响。

材料和方法

本研究使用了 PTW Semiflex 3D 31021、PinPoint 3D 31022 和 Sun Nuclear Cooperation SNC125c 电离室,在德国国家计量研究院(PTB)的实验设施中,使用 6 MV 光子束,在 0 到 1.4T 的范围内测量了这些电离室的磁场校正因子。电离室的中心轴与束轴垂直(径向)和平行(轴向)放置。在这两种情况下,磁场均垂直于束轴和电离室轴。此外,还使用聚焦质子微束和有限元法对这些电离室的灵敏体积进行了实验测定。除了磁场校正因子的模拟外,还详细应用了蒙特卡罗技术来分析空气腔内的次级电子注量,即作为磁场强度函数的次级电子数量和平均路径长度。

结果

通过微束测量和有限元计算,从 PTW 电离室的空气腔中确定了一个与腔杆相邻的非灵敏区。在本工作研究的磁场范围内,三个研究电离室的剂量响应在径向和轴向方向均不偏离无磁场情况 4%。如果在模拟中不考虑其灵敏体积,完全屏蔽的 PTW 电离室的模拟磁场校正因子会偏离 6%。在实施微束测量得出的灵敏体积后,三个电离室的实验和蒙特卡罗磁场校正因子之间可以达到 1%以内的良好一致性。详细分析表明,PTW 电离室的腔杆可能会产生屏蔽效应,从而减少磁场中进入空气腔的次级电子数量。然而,与 SNC125c 电离室相比,其空气腔内的次级电子路径长度的磁场依赖性较弱,因为 SNC125c 电离室的空气腔长度大于其直径。对于该电离室,证明了腔中的电子数量及其路径长度对磁场的依赖性更强。

讨论与结论

在 1.5T 以内的临床测量中,在两种研究的电离室取向中,三个电离室的所需校正均可以保持在 3%以内。结果再次强调了即使对于研究中的紧凑型电离室,在磁场中对电离室响应进行蒙特卡罗模拟时,考虑完全屏蔽电离室的灵敏体积的重要性。已证明所得到的与磁场相关的剂量响应取决于电离室的结构,例如空气腔的长度与直径之比以及腔杆的设计。

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