Department of Obstetrics and Gynecology, McGill University, Montréal, Quebec, Canada.
Faculty of Medicine, McGill University, Montréal, Quebec, Canada.
J Urol. 2021 Oct;206(4):978-985. doi: 10.1097/JU.0000000000001875. Epub 2021 May 25.
Our objective was to evaluate the associations with interstitial cystitis during pregnancy using a United States inpatient database.
We conducted a retrospective cohort study utilizing the Nationwide Inpatient Sample database from the Healthcare Cost and Utilization Project. ICD-9 code number 595.1 was used to extract cases of chronic interstitial cystitis and these pregnancies were compared to pregnancies without chronic interstitial cystitis, using the Chi-squared test to evaluate nominal variables. A multivariate logistic regression model was subsequently used to adjust for statistically significant confounders (p value <0.05).
There were 9,095,995 deliveries during the study period; 793 pregnant women were found to have chronic interstitial cystitis. When controlling for confounding effects in terms of pregnancy outcomes, the diagnosed group had a greater risk of developing pregnancy-induced hypertension (adjusted OR 1.57, 95% CI 1.21-2.05), preeclampsia (adjusted OR 2.06, 95% CI 1.47-2.87), preterm delivery (adjusted OR 1.63, 95% CI 1.23-2.17), preterm premature rupture of membranes (adjusted OR 2.18, 95% CI 1.25-3.79), chorioamnionitis (adjusted OR 2.05, 95% CI 1.24-3.37), delivery via cesarean section (adjusted OR 1.57, 95% CI 1.32-1.88), maternal infection (adjusted OR 2.19, 95% CI 1.40-3.43), and deep venous thromboembolism (adjusted OR 10.56, 95% CI 3.37-33.09).
Interstitial cystitis diagnosis is associated with an increased risk of preeclampsia, preterm birth, and other adverse pregnancy outcomes in this database study. Prospective studies are required to confirm the findings of the correlation between interstitial cystitis and adverse pregnancy outcomes.
本研究旨在利用美国住院患者数据库评估妊娠期间质性膀胱炎的关联。
我们利用医疗保健成本和利用项目的全国住院患者样本数据库进行了回顾性队列研究。使用 ICD-9 代码 595.1 提取慢性间质性膀胱炎病例，并将这些妊娠与无慢性间质性膀胱炎的妊娠进行比较，使用卡方检验评估名义变量。随后使用多变量逻辑回归模型调整统计学上显著的混杂因素（p 值<0.05）。
在研究期间，有 9095995 例分娩；发现 793 名孕妇患有慢性间质性膀胱炎。在控制妊娠结局方面的混杂效应后，诊断组发生妊娠高血压的风险更高（调整后的 OR 1.57，95%CI 1.21-2.05）、子痫前期（调整后的 OR 2.06，95%CI 1.47-2.87）、早产（调整后的 OR 1.63，95%CI 1.23-2.17）、早产胎膜早破（调整后的 OR 2.18，95%CI 1.25-3.79）、绒毛膜羊膜炎（调整后的 OR 2.05，95%CI 1.24-3.37）、剖宫产（调整后的 OR 1.57，95%CI 1.32-1.88）、产妇感染（调整后的 OR 2.19，95%CI 1.40-3.43）和深静脉血栓形成（调整后的 OR 10.56，95%CI 3.37-33.09）。
在本数据库研究中，间质性膀胱炎诊断与子痫前期、早产和其他不良妊娠结局的风险增加相关。需要前瞻性研究来证实间质性膀胱炎与不良妊娠结局之间的相关性。
