Gray G R, Smith I S, Mackenzie I, Gillespie G
Gastroenterology. 1978 Feb;74(2 Pt 2):397-401.
Sixty patients who had been referred for elective ulcer surgery, and in whom a remission had been induced, entered a prospective double blind controlled trial of a single daily dose of 400 mg of cimetidine given at bedtime, or placebo. Eighty per cent of patients receiving placebo suffered symptomatic relapse and recurrence of duodenal ulceration at endoscopy within 6 months. The mean interval to relapse was 10 weeks. On the other hand, only 27 percent of patients had a recurrence during the 6-month period on low dose cimetidine therapy. No significant toxic or other side effects which could be attributed to the drug were observed.
六十名因择期溃疡手术前来就诊且病情已得到缓解的患者，进入了一项前瞻性双盲对照试验，该试验中患者被随机分为两组，一组患者每晚睡前服用400毫克西咪替丁的单日剂量，另一组服用安慰剂。接受安慰剂治疗的患者中有80%在6个月内出现症状复发以及十二指肠溃疡在内镜检查下的复发。复发的平均间隔时间为10周。另一方面，在低剂量西咪替丁治疗的6个月期间，只有27%的患者出现复发。未观察到可归因于该药物的明显毒性或其他副作用。
