西咪替丁治疗一年对十二指肠溃疡或胃溃疡患者胃泌素细胞、壁细胞功能及对西咪替丁敏感性的影响。
Effect of treatment with cimetidine for one year on gastrin cell and parietal cell function and sensitivity to cimetidine in patients with duodenal or gastric ulcers.
作者信息
Festen H P, Lamers C B, Tangerman A, van Tongeren J H
出版信息
Postgrad Med J. 1980 Oct;56(660):698-701. doi: 10.1136/pgmj.56.660.698.
Twenty-two duodenal and 16 gastric ulcer patients were treated with 400 mg cimetidine twice daily for one year after their ulcers had healed. No change in gastric acid secretion was observed before and after treatment in 20 duodenal and 13 gastric ulcer patients. Similarly, the inhibitory effect of 200 mg cimetidine on gastric acid secretion was unaltered in 11 duodenal and 6 gastric ulcer patients studied and cimetidine blood concentration were unchanged in 9 duodenal and 4 gastric ulcer patients after one year. In 7 duodenal and 6 gastric ulcer patients the serum gastrin response to a standard test meal before and after treatment was identical.
22例十二指肠溃疡患者和16例胃溃疡患者在溃疡愈合后，每日两次服用400毫克西咪替丁，持续一年。20例十二指肠溃疡患者和13例胃溃疡患者在治疗前后胃酸分泌未见变化。同样，在11例接受研究的十二指肠溃疡患者和6例胃溃疡患者中，200毫克西咪替丁对胃酸分泌的抑制作用未改变，9例十二指肠溃疡患者和4例胃溃疡患者在一年后西咪替丁血药浓度未变。7例十二指肠溃疡患者和6例胃溃疡患者治疗前后对标准试餐的血清胃泌素反应相同。
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