Laboratório de Pesquisa Pré-Clínica, Faculdade de Medicina, Universidade de Nova Iguaçu, Nova Iguaçu, RJ, Brasil,
Laboratório de Pesquisa Pré-Clínica, Faculdade de Medicina, Universidade de Nova Iguaçu, Nova Iguaçu, RJ, Brasil.
Arch Endocrinol Metab. 2021 May 18;64(6):758-763. doi: 10.20945/2359-3997000000287.
The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement.
Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups.
We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment-insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively).
We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement.
本研究旨在探讨体成分和胰岛素抵抗对特纳综合征患者口服与经皮雌激素替代治疗后餐后血脂水平的影响。
评估了 25 例接受口服或经皮雌激素替代治疗的特纳综合征患者的体重指数、腰臀比和腰高比、空腹血糖、胰岛素、体成分（双能 X 射线吸收法）和餐后脂质代谢情况。为了进行统计分析，我们使用参数检验比较了两组间的数值变量。
我们观察到，接受口服与经皮激素替代治疗的患者之间餐后甘油三酯水平无差异。经皮组中，餐后甘油三酯增量与总脂肪量（p=0.02）和男性型脂肪量（p=0.02）的百分比呈正相关。在口服雌激素组中，餐后甘油三酯增量与腰臀比（p=0.15）和腰高比（p=0.009）呈正相关。经皮和口服雌激素组中，HOMA-IR 指数（homeostatic model assessment-insulin resistance，胰岛素抵抗评估的稳态模型评估指数）评估的胰岛素抵抗与雌激素替代途径之间无相关性（p=0.19 和 p=0.65）。
我们得出结论，体成分和人体测量特征可能独立于雌激素替代途径影响餐后血脂水平的程度。
