Mikami Y, Takahashi K, Yazawa K, Hour-Young C, Arai T, Saito N, Kubo A
Department of Experimental Chemotherapy, Chiba University, Japan.
J Antibiot (Tokyo). 1988 Jun;41(6):734-40. doi: 10.7164/antibiotics.41.734.
Three minor components of saframycin group antibiotics, saframycins F, G and H were isolated and their structures were determined by comparison with the spectral data of UV, IR, and 1H and 13C NMR of already reported saframycins A and D. Saframycins F, G and H were 21-cyanosaframycin D, 14-hydroxysaframycin A and 25-dihydro-25-beta-ketopropyl-saframycin A, respectively.
分离出了沙弗霉素类抗生素的三个次要成分，即沙弗霉素F、G和H，并通过与已报道的沙弗霉素A和D的紫外光谱（UV）、红外光谱（IR）以及1H和13C核磁共振谱数据进行比较确定了它们的结构。沙弗霉素F、G和H分别为21-氰基沙弗霉素D、14-羟基沙弗霉素A和25-二氢-25-β-酮丙基-沙弗霉素A。
