Department of Orthopedics, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Department of Rheumatology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Hum Vaccin Immunother. 2021 Sep 2;17(9):2954-2956. doi: 10.1080/21645515.2021.1920274. Epub 2021 May 25.
The severe acute respiratory syndrome coronavirus 2-induced coronavirus disease 2019 (COVID-19) has had a global spread. Vaccines play an essential role in preventing the spread. However, almost all types of vaccines have been reported to be associated with adverse events. Reactive arthritis (ReA) after vaccination has been reported; however, ReA after COVID-19 vaccination has not been reported. We reported a 23-year-old woman who suffered from an acute ReA on her left knee joint after COVID-19 vaccination and discussed the etiology and preventive strategy. She presented with swollen, painful left knee joint for 18 d. She had been inoculated 0.5 ml CoronaVac vaccine on 0 d and the 14th day with deltoid intramuscular injection. Finally, she was diagnosed as ReA after CoronaVac vaccination and was administered a single intra-articular injection of 1 ml compound betamethasone. The swelling and pain nearly disappeared after 2 d. On 1month follow-up, her condition was normal. ReA after COVID-19 vaccination is rare. The benefits of vaccination far outweigh its potential risks and vaccination should be administered according to the current recommendations. Further attentions should be put to determine which individual is at higher risk for developing autoimmune diseases after COVID-19 vaccination. More versatile and safer vaccines should be explored.
严重急性呼吸综合征冠状病毒 2 引起的 2019 年冠状病毒病（COVID-19）已在全球范围内传播。疫苗在预防传播方面发挥着重要作用。然而，几乎所有类型的疫苗都被报道与不良事件有关。疫苗接种后发生反应性关节炎（ReA）已有报道；然而，COVID-19 疫苗接种后发生 ReA 尚未报道。我们报告了一例 23 岁女性，在 COVID-19 疫苗接种后出现左侧膝关节急性 ReA，并讨论了病因和预防策略。她出现肿胀、疼痛的左膝关节 18 天。她于 0 天和第 14 天在三角肌进行了 0.5 毫升科兴疫苗的肌内注射。最终，她被诊断为科兴疫苗接种后的 ReA，并接受了 1 毫升复方倍他米松的单次关节内注射。2 天后肿胀和疼痛几乎消失。在 1 个月的随访中，她的病情正常。COVID-19 疫苗接种后发生 ReA 较为罕见。疫苗接种的益处远远超过其潜在风险，应根据当前建议进行接种。进一步关注的是确定哪些个体在 COVID-19 疫苗接种后发生自身免疫性疾病的风险更高。应探索更通用和更安全的疫苗。
