Sakarya University Faculty of Medicine, Division of Rheumatology, Department of Internal Medicine, Turkey.
Georgian Med News. 2021 Oct(319):100-102.
Reactive arthritis is an acute, sterile, non-suppurative and inflammatory arthropathy that usually follows infection process. Gastrointestinal, genitourinary and respiratory tract infections generally provoke reactive arthritis. Also, reactive arthritis can be seen after vaccination. Reactive arthritis cases have been reported after tetanus, combined diphteria-poliomyelitis-tetanus toxoid, hepatitis B or influenza vaccination. Although reactive arthritis is more common in youngs, healthcare workers should be aware of the development of post inactivated COVID-19 vaccine reactive arthritis in older patients. We present two cases with ReA induced by inactivated coronavirus 2019 (COVID-19) vaccination (CoronaVac, Sinovac). Both patients in our study were over 70 years old and presented with polyarthritis that developed after vaccination. Rheumatoid factor and anti-nucleer antibody were negative and patients responded well to short-term steroid therapy, arthritis were not resistant.
反应性关节炎是一种急性、无菌性、非化脓性和炎症性关节炎，通常继发于感染过程。胃肠道、泌尿生殖道和呼吸道感染通常会引发反应性关节炎。此外，反应性关节炎也可能在接种疫苗后发生。接种破伤风、白喉-百日咳-破伤风联合疫苗、乙肝或流感疫苗后，曾有反应性关节炎的病例报告。尽管反应性关节炎在年轻人中更为常见，但医护人员应该意识到，在老年患者中，接种灭活 COVID-19 疫苗后可能会发生反应性关节炎。我们报告了两例由 2019 年冠状病毒病（COVID-19）灭活疫苗（科兴中维）接种引起的反应性关节炎（ReA）。我们研究中的这两名患者均年龄超过 70 岁，在接种疫苗后出现多发性关节炎。类风湿因子和抗核抗体均为阴性，患者对短期类固醇治疗反应良好，关节炎无耐药性。
