Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Centers for Personalized Medicine (ZPM) Baden-Wuerttemberg, Germany.
Department of Clinical Genetics and Pathology, Office for Medical Services, Region Skåne, Lund, Sweden; Genomic Medicine Sweden (GMS), Sweden.
Semin Cancer Biol. 2022 Sep;84:242-254. doi: 10.1016/j.semcancer.2021.05.026. Epub 2021 May 24.
Over the last decades, rapid technological and scientific advances have led to a merge of molecular sciences and clinical medicine, resulting in a better understanding of disease mechanisms and the development of novel therapies that exploit specific molecular lesions or profiles driving disease. Precision oncology is here used as an example, illustrating the potential of precision/personalized medicine that also holds great promise in other medical fields. Real-world implementation can only be achieved by dedicated healthcare connected centers which amass and build up interdisciplinary expertise reflecting the complexity of precision medicine. Networks of such centers are ideally suited for a nation-wide outreach offering access to precision medicine to patients independent of their place of residence. Two of these multicentric initiatives, Genomic Medicine Sweden (GMS) and the Centers for Personalized Medicine (ZPM) initiative in Germany have teamed up to present and share their views on core concepts, potentials, challenges, and future developments in precision medicine. Together with other initiatives worldwide, GMS and ZPM aim at providing a robust and sustainable framework, covering all components from technology development to clinical trials, ethical and legal aspects as well as involvement of all relevant stakeholders, including patients and policymakers in the field.
在过去的几十年里，快速的技术和科学进步导致了分子科学和临床医学的融合，从而更好地理解了疾病的机制，并开发了利用特定分子病变或驱动疾病的特征的新型疗法。精准肿瘤学就是一个很好的例子，它说明了精准/个性化医学的潜力，这在其他医学领域也有很大的前景。只有通过专门的医疗保健中心来实现现实世界的实施，这些中心汇集并建立跨学科的专业知识，反映出精准医学的复杂性。这些中心的网络非常适合全国范围内的推广，为患者提供精准医学服务，而不论其居住地点如何。这两个多中心倡议，瑞典基因组医学（GMS）和德国个性化医学中心（ZPM）倡议联手展示并分享他们对精准医学的核心概念、潜力、挑战和未来发展的看法。与全球其他倡议一起，GMS 和 ZPM 旨在提供一个强大和可持续的框架，涵盖从技术开发到临床试验、伦理和法律方面以及包括患者和政策制定者在内的所有相关利益相关者参与的所有组成部分。
