Edsjö Anders, Palmqvist Richard, Haglund Felix, Helenius Gisela, Lindqvist Oscar, Fagman Henrik, Botling Johan
PhD, överläkare, klinisk genetik och patologi,, Skånes universitetssjukhus; Lunds universitet.
professor, överläkare, Region Västerbotten; Umeå universitet.
Lakartidningen. 2021 May 10;118:20209.
Rapidly expanding knowledge of the molecular landscape of cancers has resulted in the implementation of an increasing number of specific therapies targeted at tumors with specific molecular aberrations. In response to this development, new tools for predictive testing for molecular targets need to be implemented in routine health care. To achieve robust future molecular diagnostic pathology, and equal opportunity for patients to qualify for targeted therapy, the national working group for Solid Tumors in the initiative Genomic Medicine Sweden (GMS) aims to implement regional and national platforms for comprehensive genomic tumor profiling and linked analysis pipelines. Novel IT-infrastrucutures and recruitment of bioinformaticians and molecular biologists to hospital labotatories are paramount. The infrastructure will allow wider inclusion into clinical trials and supplement the national cancer registries with molecular »real world data« for research and evaluation of implemented cancer therapies and diagnostic procedures.
癌症分子格局知识的迅速扩展,已促使越来越多针对具有特定分子异常的肿瘤的特异性疗法得以应用。针对这一发展趋势,需要在常规医疗保健中采用新的分子靶点预测检测工具。为实现未来强大的分子诊断病理学,并为患者提供获得靶向治疗的平等机会,瑞典基因组医学倡议(GMS)中的实体瘤国家工作组旨在建立区域和国家平台,用于全面的基因组肿瘤分析及相关分析流程。至关重要的是要有新颖的信息技术基础设施,并招聘生物信息学家和分子生物学家到医院实验室工作。该基础设施将使更多患者能够纳入临床试验,并为国家癌症登记处补充分子“真实世界数据”,用于研究和评估已实施的癌症治疗方法和诊断程序。