X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
X-Chem Inc., 100 Beaver Street, Waltham, MA 02453, USA.
Bioorg Med Chem. 2021 Jul 1;41:116189. doi: 10.1016/j.bmc.2021.116189. Epub 2021 May 1.
An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade's worth of DEL-driven screening.
砌块（BB）包容性和原子经济性文库方案的方法可提供最适合小分子药物发现的 DNA 编码文库的质量和多样性。在本观点中，我们提供了十年来 DEL 驱动筛选中 DEL 设计的关键经验教训。
