[Analysis of serum allergen-specific IgE in children with respiratory allergic disease in Guangdong].

To investigate the common allergens in children with respiratory allergic diseases in Guangdong and provide the basis for preventing and treating respiratory allergic diseases. A total of 254 serum samples were collected retrospectively from children with allergic rhinitis and (or) asthma in the pediatric clinic of the First Affiliated Hospital of Guangzhou Medical University or Boai Hospital of Zhongshan City from August 2019 to August 2020 and tested positive for at least one allergens by ImmunoCAP 1000 or skin prick test. There were 173 males and 81 females, with a median age (interquartile interval) of 7 (4.00, 9.75) years. Specific IgE against eighteen common allergen were tested by magnetic particle chemiluminescence immunoassay. Statistical analysis using χ test. The positive rate of (85.0%, 215/254) was the highest, followed by (83.5%, 212/254), egg white (19.3%, 49/254), milk (14.6%, 37/254), German cockroach (14.2%, 36/254) and ox-eye daisy (12.6%, 32/254). Dust mites were the most common allergens in patients with allergic rhinitis / allergic asthma / allergic rhinitis and asthma. The positive rates of (95.4% vs. 91.7% vs. 71.0%, χ=23.257, <0.001), (95.4% vs. 90.6% vs. 67.7%, χ=26.916, <0.001), mugwort (10.8% vs. 9.4% vs. 1.1%, χ=7.535, =0.023), and ox-eye daisy (21.5% vs. 14.6% vs. 4.3%, χ=10.876, =0.004) in allergic rhinitis combined with asthma group and allergic rhinitis group were significantly higher than those in allergic rhinitis group. The positive rates of (96.2% vs. 84.0% vs. 53.5%, χ=46.343, <0.001), (96.2% vs. 81.5% vs. 48.8%, χ=52.756, <0.001) and German cockroach (17.7% vs. 14.8% vs. 2.3%, χ=6.313, =0.043) in > 6 years old group were significantly higher than those in > 3 years old group and > 3-6 years old group, while the sIgE positive rates of egg white (41.9% vs. 21.0% vs. 10.8%, χ=20.281, <0.001) and milk (41.9% vs. 16.0% vs. 4.6%, χ=36.227, <0.001) in ≤3 years old group were significantly higher than those in > 3-6 years old group and > 6 years old group. In addition, there were significant positive correlations between and , mugwort and ox-eye daisy, cat dander and horse dander, ox-eye daisy and dandelion, egg white and milk, timothy grass and sesame (≥0.511, < 0.01). With the increase of the class of house dust mite allergen, the sIgE positive rates of mugwort (0.0% vs. 1.5% vs. 10.8%, χ=9.714, =0.008), ox-eye daisy (0.0% vs. 4.4% vs. 19.6%, χ=16.195, <0.001), cat dander (0.0% vs. 7.4% vs. 18.2%, χ=11.459, =0.003) and horse dander (0.0% vs. 1.5% vs. 15.5%, χ=15.443, < 0.001) increased significantly, while the sIgE positive rate of milk (29.0% vs. 16.2% vs. 10.1%, χ=8.792, =0.012) decreased significantly. Dust mite is the main allergen in children with respiratory allergic diseases in Guangdong, and ox-eye daisy is the main pollen allergen. The sensitization patterns of allergens varied in different ages and diseases, and children with respiratory allergic diseases should regularly detect allergens and pay attention to avoid them.