Berners-Lee Alice, Wu Xiaojing, Foster David J
Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, California 94720.
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
J Neurosci. 2021 Jul 7;41(27):5894-5908. doi: 10.1523/JNEUROSCI.1158-20.2021.
Diverse functions such as decision-making and memory consolidation may depend on communication between neurons in the hippocampus (HP) and prefrontal cortex (PFC). HP replay is a candidate mechanism to facilitate this communication, however details remain largely unknown because of the technical challenges of recording sufficient numbers of HP neurons for replay while also recording PFC neurons. Here, we implanted male rats with 40-tetrode drives, split between HP and PFC, during learning of a Y-maze spatial memory task. Surprisingly, we found that in contrast to their non-selectivity for maze arm during movement, a portion of PFC neurons were highly selective for HP replay of different arms. Moreover, PFC neurons' selectivity to HP non-local arm representation during running tended to match their replay arm selectivity and was predictive of future choice. Thus, PFC activity that is tuned to HP activity is best explained by non-local HP position representations rather than HP representation of actual position, providing a new potential mechanism of HP-PFC coordination during HP replay. The hippocampus (HP) is implicated in spatial learning while the prefrontal cortex (PFC) is implicated in decision-making. The question of how the two areas interact has been of great interest. A specific activity type in HP called replay is particularly interesting because it resembles internal exploration of non-local experiences, but is technically challenging to study, requiring recordings from large numbers of HP neurons simultaneously. Here, we combined replay recordings from HP with prefrontal recordings, to reveal a surprising degree of selectivity for replay, and a pattern of coordination that supports some conceptions of hippocampocortical interaction and challenges others.
诸如决策和记忆巩固等多种功能可能依赖于海马体（HP）和前额叶皮质（PFC）中神经元之间的交流。海马体重演是促进这种交流的一种潜在机制，然而，由于在记录足够数量的用于重演的海马体神经元同时还要记录前额叶皮质神经元存在技术挑战，其细节在很大程度上仍不为人知。在这里，我们在雄性大鼠学习Y迷宫空间记忆任务期间，为它们植入了40通道的四极管驱动器，分别置于海马体和前额叶皮质。令人惊讶的是，我们发现，与它们在运动过程中对迷宫臂的非选择性不同，一部分前额叶皮质神经元对不同臂的海马体重演具有高度选择性。此外，前额叶皮质神经元在奔跑过程中对海马体非局部臂表征的选择性往往与其重演臂选择性相匹配，并且可以预测未来的选择。因此，根据非局部海马体位置表征而非实际位置的海马体表征来解释与海马体活动相匹配的前额叶皮质活动，为海马体重演期间海马体 - 前额叶皮质协调提供了一种新的潜在机制。海马体（HP）与空间学习有关，而前额叶皮质（PFC）与决策有关。这两个区域如何相互作用的问题一直备受关注。海马体中一种名为重演的特定活动类型尤其有趣，因为它类似于对非局部经历的内部探索，但在技术上难以研究，需要同时记录大量海马体神经元。在这里，我们将海马体的重演记录与前额叶记录相结合，揭示了对重演惊人程度的选择性，以及一种支持海马体 - 皮质相互作用某些概念并对其他概念提出挑战的协调模式。
