The UCL Max Planck Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
Wellcome Centre for Human Neuroimaging, University College London, London, UK.
Nat Neurosci. 2023 Apr;26(4):627-637. doi: 10.1038/s41593-023-01287-7. Epub 2023 Apr 5.
Neural replay is implicated in planning, where states relevant to a task goal are rapidly reactivated in sequence. It remains unclear whether, during planning, replay relates to an actual prospective choice. Here, using magnetoencephalography (MEG), we studied replay in human participants while they planned to either approach or avoid an uncertain environment containing paths leading to reward or punishment. We find evidence for forward sequential replay during planning, with rapid state-to-state transitions from 20 to 90 ms. Replay of rewarding paths was boosted, relative to aversive paths, before a decision to avoid and attenuated before a decision to approach. A trial-by-trial bias toward replaying prospective punishing paths predicted irrational decisions to approach riskier environments, an effect more pronounced in participants with higher trait anxiety. The findings indicate a coupling of replay with planned behavior, where replay prioritizes an online representation of a worst-case scenario for approaching or avoiding.
神经重放与规划有关，在规划中，与任务目标相关的状态会迅速按顺序重新激活。目前尚不清楚在规划过程中，重放是否与实际的前瞻性选择有关。在这里，我们使用脑磁图（MEG）研究了人类参与者在计划接近或回避包含通往奖励或惩罚路径的不确定环境时的重放。我们发现了在规划过程中进行正向顺序重放的证据，状态到状态的快速转换发生在 20 到 90 毫秒之间。在决定回避之前，奖励路径的重放相对于惩罚路径得到了增强，而在决定接近之前则减弱了。在一项试验中，偏向于重放预期的惩罚路径的倾向预测了冒险接近风险环境的不合理决策，这种效应在具有较高特质焦虑的参与者中更为明显。研究结果表明，重放与计划行为相关联，其中重放优先考虑接近或回避的最坏情况的在线表示。
