Hirigo Agete Tadewos, Teshome Tesfaye, Abera Gitore Wondwossen, Worku Endale
College of Medicine and Health Science, Faculty of Medicine, School of Medical Laboratory Sciences, Hawassa University, Hawassa City, Sidama Regional State, Southern-Ethiopia.
College of Medicine and Health Science, Faculty of Medicine, Physiology Unit, Hawassa University, Hawassa City, Sidama Regional State, Southern-Ethiopia.
Nutr Metab Insights. 2021 May 17;14:11786388211016842. doi: 10.1177/11786388211016842. eCollection 2021.
Dyslipidemia is one of the adverse metabolic outcomes associated with psychotropic medications and the nature of the mental illness itself. Therefore, this study aimed to assess magnitude of dyslipidemia and associated factors among patients with severe mental illness on antipsychotic treatments.
A cross-sectional study was conducted among 245 patients with severe mental illness in Hawassa University Comprehensive Specialized Hospital, Sidama Regional state, Southern Ethiopia. Socio-demographic and other important data were collected using a structured questionnaire through a systematic random sampling technique. Individual dyslipidemia was characterized by the National Cholesterol Education Program Adult Treatment Panel-III (NCEP ATP-III) guideline.
Mean total cholesterol (TC) was significantly higher in males when compared to females (162.2 mg/dl vs 121 mg/dl, = .023). While, mean LDL-cholesterol was significantly higher in females when compared to males (100.9 mg/dl vs 93.6 mg/dl, = .028). Overall 58.4% (95% CI: 52.2-64.8) of participants had at least 1 dyslipidemia. The prevalence of TC ⩾200 mg/dl, HDL-cholesterol <40 mg/dl, triglyceride (TG) and LDL-cholesterol were 61 (24.9%), 75 (30.6%), 66 (26.9%), and 47 (19.2%), respectively. Female sex and smoking were significantly and positively associated with LDL-c dyslipidemia, the aOR (95% CI) were 2.1 (1.0-4.2) for female sex and 3.4 (1.1-10.5) for smoking. Also, Age >40 years was significantly associated with TC dyslipidemia, the aOR (95% CI) was 2.0 (1.1-3.7).
More than half of psychiatric patients are at risk of developing cardiovascular and other related health problems. Therefore, periodic screening of lipid profiles during healthcare follow-up is mandatory to limit risks of cardiovascular-related comorbidities among patients with severe mental illness.
血脂异常是与精神药物以及精神疾病本身相关的不良代谢后果之一。因此，本研究旨在评估接受抗精神病治疗的重度精神疾病患者中血脂异常的程度及相关因素。
在埃塞俄比亚南部锡达马地区州哈瓦萨大学综合专科医院对245例重度精神疾病患者进行了一项横断面研究。通过系统随机抽样技术，使用结构化问卷收集社会人口学和其他重要数据。个体血脂异常根据美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP ATP-III）指南进行界定。
男性的平均总胆固醇（TC）显著高于女性（162.2mg/dl对121mg/dl，P = 0.023）。而女性的平均低密度脂蛋白胆固醇（LDL-C）显著高于男性（100.9mg/dl对93.6mg/dl，P = 0.028）。总体而言，58.4%（95%CI：52.2 - 64.8）的参与者至少有一种血脂异常。TC≥200mg/dl、高密度脂蛋白胆固醇（HDL-C）<40mg/dl、甘油三酯（TG）和LDL-C的患病率分别为61例（24.9%）、75例（30.6%）、66例（26.9%）和47例（19.2%）。女性和吸烟与LDL-C血脂异常显著正相关，女性的调整后比值比（aOR，95%CI）为2.1（1.0 - 4.2），吸烟的为3.4（1.1 - 10.5）。此外，年龄>40岁与TC血脂异常显著相关，aOR（95%CI）为2.0（1.1 - 3.7）。
超过一半的精神科患者有发生心血管及其他相关健康问题的风险。因此，在医疗随访期间定期筛查血脂谱对于限制重度精神疾病患者心血管相关合并症的风险是必不可少的。
