Wong M, Carter D R
Rehabilitation Research and Development Center, Veterans Administration Medical Center, Palo Alto, California.
J Bone Joint Surg Am. 1988 Aug;70(7):992-1000.
The possible role of mechanical stress in determining the patterns of endochondral ossification in skeletal anlages was explored using stress-analysis computer models of developing human sterna. It has been hypothesized previously that the normal sequence of proliferation, maturation, degeneration, and ossification of cartilage is accelerated in regions of high cyclic octahedral shear stress and inhibited in regions of intermittent compressive-hydrostatic (dilatational) stress. This hypothesis was investigated using two-dimensional, all-cartilage, plane-stress finite-element models of the three basic shapes of human sterna that were identified by Ashley. A mathematical criterion, which combined the opposing influences of the shear and dilatational stresses into a single net stimulus for ossification, was used successfully to simulate the three basic patterns of sternal endochondral ossification that were previously documented. Our findings support the view that mechanical forces may strongly influence skeletal morphogenesis, growth, and development, beginning at a very early stage.
利用发育中的人类胸骨的应力分析计算机模型，探讨了机械应力在决定骨骼原基软骨内成骨模式中的可能作用。此前已有假说认为，软骨增殖、成熟、退变和骨化的正常顺序在高循环八面体剪应力区域会加速，而在间歇性压缩静水（膨胀）应力区域会受到抑制。使用阿什利确定的人类胸骨三种基本形状的二维全软骨平面应力有限元模型对这一假说进行了研究。一种数学标准成功地模拟了先前记录的胸骨软骨内成骨的三种基本模式，该标准将剪应力和膨胀应力的相反影响合并为一个单一的骨化净刺激。我们的研究结果支持这样一种观点，即机械力可能从很早的阶段就强烈影响骨骼的形态发生、生长和发育。
