Mansour Mahmoud M, Smith Zachary D, Ghouri Yezaz, Tahan Veysel
Internal Medicine, University of Missouri School of Medicine, Columbia, USA.
Internal Medicine/Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, USA.
Cureus. 2021 Apr 20;13(4):e14591. doi: 10.7759/cureus.14591.
Serrated polyposis syndrome (SPS) is a pre-cancerous condition associated with increased risk of developing colorectal cancer (CRC). Its role in inflammatory bowel disease (IBD)-associated CRC remains unknown. Despite the growing understanding and recognition of SPS, there is limited literature about its impact on the colon in individuals with IBD. Herein, we report a case of a 45-year-old female who was diagnosed with ulcerative colitis (UC) and SPS. We also reviewed the literature surrounding this association and highlighted the intricacies in managing this unique patient population. At present, there are no screening guidelines for CRC in SPS patients with IBD. However, given the potential synergistic risk for CRC, a close surveillance approach may be utilized. Tracking lifetime cumulative features of SPS and endoscopic clearance of adenomas and serrated polyps are the mainstays of management.
锯齿状息肉综合征（SPS）是一种癌前病变，与患结直肠癌（CRC）的风险增加相关。其在炎症性肠病（IBD）相关结直肠癌中的作用尚不清楚。尽管对SPS的认识和了解不断增加，但关于其对IBD患者结肠影响的文献有限。在此，我们报告一例45岁女性，她被诊断为溃疡性结肠炎（UC）和SPS。我们还回顾了围绕这种关联的文献，并强调了管理这一独特患者群体的复杂性。目前，对于患有IBD的SPS患者没有结直肠癌筛查指南。然而，鉴于患结直肠癌的潜在协同风险，可采用密切监测方法。追踪SPS的终生累积特征以及腺瘤和锯齿状息肉的内镜清除情况是管理的主要内容。
