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麻醉选择在围手术期出血中的作用。

The Role of Anesthetic Selection in Perioperative Bleeding.

机构信息

Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, USA.

Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.

出版信息

Biomed Res Int. 2021 May 7;2021:5510634. doi: 10.1155/2021/5510634. eCollection 2021.

DOI:10.1155/2021/5510634
PMID:34036098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8123995/
Abstract

Perioperative bleeding is one of the major comorbidities associated with surgery. While anesthesia is a critical component to perform surgery, a number of clinical studies supported the contribution of anesthetic drugs to perioperative bleeding. Here, we reviewed the literature on this topic including the underlying mechanism and discussed the future direction on coagulation research in anesthesia.

摘要

围手术期出血是与手术相关的主要合并症之一。虽然麻醉是进行手术的关键组成部分,但许多临床研究支持麻醉药物对围手术期出血的贡献。在这里,我们回顾了关于这个主题的文献,包括潜在的机制,并讨论了麻醉中凝血研究的未来方向。

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The Role of Anesthetic Selection in Perioperative Bleeding.麻醉选择在围手术期出血中的作用。
Biomed Res Int. 2021 May 7;2021:5510634. doi: 10.1155/2021/5510634. eCollection 2021.
2
Economic considerations of the use of new anesthetics: a comparison of propofol, sevoflurane, desflurane, and isoflurane.新型麻醉剂使用的经济学考量:丙泊酚、七氟烷、地氟烷和异氟烷的比较
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Anesthesiology. 2000 Dec;93(6):1401-6. doi: 10.1097/00000542-200012000-00010.

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Clin Case Rep. 2025 May 16;13(5):e70519. doi: 10.1002/ccr3.70519. eCollection 2025 May.
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General anesthesia with nerve blocks for a patient with femoral fracture and essential thrombocythemia: a case report.全麻联合神经阻滞用于股骨骨折合并原发性血小板增多症患者:病例报告。
J Int Med Res. 2023 Sep;51(9):3000605231198385. doi: 10.1177/03000605231198385.

本文引用的文献

1
Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation.中性粒细胞通过塑造血小板聚集的流变环境促进静脉血栓形成。
Sci Rep. 2019 Nov 4;9(1):15932. doi: 10.1038/s41598-019-52041-8.
2
Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function .用于评估血小板激动剂和抗血小板化合物对血小板功能影响的血小板聚集测定法。
MethodsX. 2018 Dec 26;6:63-70. doi: 10.1016/j.mex.2018.12.012. eCollection 2019.
3
Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds.挥发性麻醉剂可减弱吞噬细胞功能,并使伤口细菌负荷恶化。
J Surg Res. 2019 Jan;233:323-330. doi: 10.1016/j.jss.2018.07.075. Epub 2018 Sep 5.
4
From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.封面文章:长时间暴露于挥发性麻醉剂异氟烷会使多微生物性腹部脓毒症的预后恶化。
Toxicol Sci. 2017 Apr 1;156(2):402-411. doi: 10.1093/toxsci/kfw261.
5
Sevoflurane attenuates platelets activation of patients undergoing lung cancer surgery and suppresses platelets-induced invasion of lung cancer cells.七氟醚可减轻肺癌手术患者的血小板活化,并抑制血小板诱导的肺癌细胞侵袭。
J Clin Anesth. 2016 Dec;35:304-312. doi: 10.1016/j.jclinane.2016.08.008. Epub 2016 Oct 12.
6
Cardiopulmonary bypass in the pediatric population.儿科人群中的体外循环
Best Pract Res Clin Anaesthesiol. 2015 Jun;29(2):241-56. doi: 10.1016/j.bpa.2015.03.006. Epub 2015 Apr 8.
7
Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen.挥发性麻醉剂对白细胞整合素巨噬细胞-1抗原的不同作用
J Immunotoxicol. 2016;13(2):148-56. doi: 10.3109/1547691X.2015.1019596. Epub 2015 Mar 9.
8
Effects of isoflurane, sevoflurane, and desflurane on platelet function: A prospective, randomized, single-blind, in vivo study.异氟烷、七氟烷和地氟烷对血小板功能的影响:一项前瞻性、随机、单盲体内研究。
Curr Ther Res Clin Exp. 2005 Jul;66(4):375-84. doi: 10.1016/j.curtheres.2005.08.010.
9
TEG and ROTEM: technology and clinical applications.血栓弹力图(TEG)和旋转血栓弹性测定仪(ROTEM):技术与临床应用。
Am J Hematol. 2014 Feb;89(2):228-32. doi: 10.1002/ajh.23599.
10
Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1.丙泊酚与异氟醚和七氟醚在白细胞功能相关抗原-1上共享结合位点。
Anesth Analg. 2013 Oct;117(4):803-811. doi: 10.1213/ANE.0b013e3182a00ae0. Epub 2013 Aug 19.