Humphries Brittany, Collins Stéphanie, Guillaumie Laurence, Lemieux Julie, Dionne Anne, Provencher Louise, Moisan Jocelyne, Lauzier Sophie
Population Health and Optimal Health Practices, CHU de Quebec⁻Université Laval Research Centre, Hôpital du Saint-Sacrement, 1050 chemin Ste-Foy, Quebec, QC G1S 4L8, Canada.
Faculty of Pharmacy, Université Laval, 1050 avenue de la Médecine, Quebec, QC G1V 0A6, Canada.
Pharmacy (Basel). 2018 Jun 9;6(2):53. doi: 10.3390/pharmacy6020053.
Adjuvant endocrine therapy (AET) taken for a minimum of five years reduces the recurrence and mortality risks among women with hormone-sensitive breast cancer. However, adherence to AET is suboptimal. To guide the development of theory-based interventions to enhance AET adherence, we conducted a study to explore beliefs regarding early adherence to AET. This qualitative study was guided by the Theory of Planned Behavior (TPB). We conducted focus groups and individual interviews among women prescribed AET in the last two years ( = 43). The topic guide explored attitudinal (perceived advantages and disadvantages), normative (perception of approval or disapproval), and control beliefs (barriers and facilitating factors) towards adhering to AET. Thematic analysis was conducted. Most women had a positive attitude towards AET regardless of their medication-taking behavior. The principal perceived advantage was protection against a recurrence while the principal inconvenience was side effects. Almost everyone approved of the woman taking her medication. The women mentioned facilitating factors to encourage medication-taking behaviors and cope with side effects. For adherent women, having trouble establishing a routine was their main barrier to taking medication. For non-adherent women, it was side effects affecting their quality of life. These findings could inform the development of community pharmacy-based adherence interventions.
辅助内分泌治疗（AET）持续至少五年可降低激素敏感性乳腺癌女性的复发和死亡风险。然而，AET的依从性并不理想。为指导基于理论的干预措施的开发以提高AET依从性，我们开展了一项研究以探索关于早期坚持AET的信念。这项定性研究以计划行为理论（TPB）为指导。我们在过去两年中接受AET治疗的女性（n = 43）中进行了焦点小组和个人访谈。主题指南探讨了对坚持AET的态度（感知的优点和缺点）、规范信念（对认可或不认可的感知）以及控制信念（障碍和促进因素）。进行了主题分析。无论其服药行为如何，大多数女性对AET持积极态度。主要感知到的优点是预防复发，而主要不便之处是副作用。几乎每个人都赞成女性服药。这些女性提到了鼓励服药行为和应对副作用的促进因素。对于坚持服药的女性，难以建立规律是她们服药的主要障碍。对于不坚持服药的女性，是副作用影响了她们的生活质量。这些发现可为基于社区药房的依从性干预措施的开发提供参考。
