Cho Chris, Liu Melissa M, Channa Roomasa, Zhang Alice Y, Quigley Harry A, Jefferys Joan L, Scott Adrienne W
School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Retina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
J Vitreoretin Dis. 2019 Jan;3(1):16-20. doi: 10.1177/2474126418810146. Epub 2018 Nov 20.
The purpose of this study is to determine the sensitivity and specificity of detecting age-related macular degeneration (AMD) using portable optical coherence tomography (OCT) operated by nonexpert photographers on undilated patients.
In this case-control study, 92 individuals were recruited from the glaucoma and retina clinics at the Wilmer Eye Institute (Johns Hopkins University, Baltimore, MD). Using the portable iVue (Optovue, Inc, Fremont, CA) spectral-domain OCT (SD-OCT), 2 nonexpert photographers acquired retina map scans on undilated eyes of all participants. In total, 33 AMD eyes and 105 control eyes were evaluated and graded by ophthalmologists masked to the diagnoses.
Detection of AMD on the portable OCT by ophthalmologists exhibited sensitivities of 0.91 and 0.94 and specificities of 0.88 and 0.89, for graders 1 and 2, respectively. A strong intergrader agreement was observed (κ = 0.87).
Nonexpert photographers can use a portable OCT on undilated eyes to acquire images for the detection of AMD. These findings present the potential utility of implementing a portable OCT in community screenings for earlier detection and treatment of disease.
本研究旨在确定由非专业摄影师操作的便携式光学相干断层扫描（OCT）在未散瞳患者中检测年龄相关性黄斑变性（AMD）的敏感性和特异性。
在这项病例对照研究中，从威尔默眼科研究所（约翰霍普金斯大学，巴尔的摩，马里兰州）的青光眼和视网膜诊所招募了92名个体。使用便携式iVue（Optovue公司，弗里蒙特，加利福尼亚州）光谱域OCT（SD - OCT），两名非专业摄影师对所有参与者未散瞳的眼睛进行视网膜地图扫描。总共对33只AMD眼睛和105只对照眼睛进行了评估，并由对诊断不知情的眼科医生进行分级。
眼科医生通过便携式OCT检测AMD时，1级和2级分级者的敏感性分别为0.91和0.94，特异性分别为0.88和0.89。观察到分级者之间有很强的一致性（κ = 0.87）。
非专业摄影师可以使用便携式OCT对未散瞳的眼睛进行成像以检测AMD。这些发现表明在社区筛查中使用便携式OCT进行疾病早期检测和治疗具有潜在的实用性。
