抗VEGF药物治疗新生血管性年龄相关性黄斑变性：长期视力预后的预测因素
Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes.
作者信息
Pedrosa Ana Catarina, Sousa Tiago, Pinheiro-Costa João, Beato João, Falcão Manuel S, Falcão-Reis Fernando, Carneiro Angela
机构信息
Department of Ophthalmology, Centro Hospitalar São João, Porto, Portugal.
Department of Sense Organs, Faculty of Medicine of the University of Porto, Porto, Portugal.
出版信息
J Ophthalmol. 2017;2017:4263017. doi: 10.1155/2017/4263017. Epub 2017 Jun 1.
PURPOSE
To evaluate the predictive factors of long-term visual outcomes in neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) agents.
METHODS
Unicentric retrospective review of patients with nAMD treated with anti-VEGF agents. Visual outcomes, 12 and 60 months after diagnosis, were evaluated. In an attempt to identify predictive factors of visual outcomes, multiple variables (demographic and epidemiological characteristics, angiographic and tomographic features) were analyzed, at baseline and during follow-up.
RESULTS
One hundred and seventeen patients were included. In multivariate analysis, baseline best-corrected visual acuity was associated with all visual endpoints at 12 and 60 months. Additionally, age, gender, number of injections, and development of subretinal fibrosis during follow-up were also significant predictors of visual outcomes at 60 months.
CONCLUSIONS
Several factors can be useful in clinical practice as predictors of visual outcomes in response to anti-VEGF treatment of nAMD.
目的
评估抗血管内皮生长因子（anti-VEGF）药物治疗新生血管性年龄相关性黄斑变性（nAMD）后长期视力预后的预测因素。
方法
对接受anti-VEGF药物治疗的nAMD患者进行单中心回顾性研究。评估诊断后12个月和60个月时的视力预后。为了确定视力预后的预测因素，分析了基线和随访期间的多个变量（人口统计学和流行病学特征、血管造影和断层扫描特征）。
结果
纳入117例患者。多变量分析显示，基线最佳矫正视力与12个月和60个月时的所有视力终点相关。此外，年龄、性别、注射次数以及随访期间视网膜下纤维化的发生也是60个月时视力预后的重要预测因素。
结论
在临床实践中，有几个因素可作为nAMD抗VEGF治疗后视力预后的预测指标。
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