Rahmanian-Devin Pouria, Baradaran Rahimi Vafa, Askari Vahid Reza
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Adv Pharmacol Pharm Sci. 2021 May 5;2021:6640893. doi: 10.1155/2021/6640893. eCollection 2021.
Today, with the advances in technology and science, more advanced drug delivery formulations are required. One of these new systems is an intelligent hydrogel. These systems are affected by the environment or conditions that become a gel, stay in the circumstance for a certain period, and slowly release the drug. As an advantage, only a lower dose of the drug is required, and it provides less toxicity and minor damage to other tissues. Hydrogels are of different types, including temperature-sensitive, pH-sensitive, ion change-sensitive, and magnetic field-sensitive. In this study, we investigated a kind of temperature-sensitive smart hydrogel, which has a liquid form at room temperature and becomes gel with increasing temperature. Chitosan--glycerophosphate hydrogels have been researched and used in many studies. This study investigates the various factors that influence the gelation mechanism, such as gel formation rates, temperature, pH, time, and gel specificity. Hydrogels are used in many drug delivery systems and diseases, including nasal drug delivery, vaginal drug delivery, wound healing, peritoneal adhesion, ophthalmic drug delivery, tissue engineering, and peptide and protein delivery. Overall, the chitosan--glycerophosphate hydrogel is a suitable drug carrier for a wide range of drugs. It shows little toxicity to the body, is biodegradable, and is compatible with other organs. This system can be used in different conditions and different medication ways, such as oral, nasal, and injection.
如今，随着科技的进步，需要更先进的药物递送制剂。这些新系统之一是智能水凝胶。这些系统会受到环境或条件的影响，形成凝胶，在该环境中停留一段时间，并缓慢释放药物。其优点是只需要较低剂量的药物，且毒性较小，对其他组织的损伤也较小。水凝胶有不同类型，包括温度敏感型、pH敏感型、离子变化敏感型和磁场敏感型。在本研究中，我们研究了一种温度敏感型智能水凝胶，它在室温下呈液体形式，随着温度升高变成凝胶。壳聚糖-甘油磷酸盐水凝胶已在许多研究中得到研究和应用。本研究考察了影响凝胶化机制的各种因素，如凝胶形成速率、温度、pH值、时间和凝胶特异性。水凝胶被用于许多药物递送系统和疾病治疗中，包括鼻腔给药、阴道给药、伤口愈合、腹膜粘连、眼科给药、组织工程以及肽和蛋白质递送。总体而言，壳聚糖-甘油磷酸盐水凝胶是多种药物的合适药物载体。它对身体毒性小，可生物降解，且与其他器官兼容。该系统可用于不同条件和不同给药方式，如口服、鼻腔给药和注射。
