Parvin Nargish, Joo Sang Woo, Mandal Tapas Kumar
School of Mechanical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Gels. 2025 May 23;11(6):383. doi: 10.3390/gels11060383.
Injectable biopolymer-based hydrogels have emerged as a powerful class of biomaterials designed for minimally invasive therapeutic strategies in modern medicine. These smart hydrogels, derived from natural biopolymers, such as alginate, chitosan, gelatin, hyaluronic acid, and collagen, offer unique advantages, including biocompatibility, biodegradability, and the ability to mimic the extracellular matrix. This review provides a comprehensive overview of recent advancements in the design, crosslinking mechanisms, and biofunctionality of injectable hydrogels tailored for targeted drug delivery and tissue regeneration. Special attention is given to their role in in situ gelling systems, cancer therapy, musculoskeletal repair, and neural regeneration. Challenges related to mechanical strength, degradation control, and clinical translation are also discussed, along with future perspectives for scalable manufacturing and regulatory approval.
基于可注射生物聚合物的水凝胶已成为一类强大的生物材料，专为现代医学中的微创治疗策略而设计。这些源自天然生物聚合物（如藻酸盐、壳聚糖、明胶、透明质酸和胶原蛋白）的智能水凝胶具有独特优势，包括生物相容性、生物可降解性以及模拟细胞外基质的能力。本综述全面概述了用于靶向药物递送和组织再生的可注射水凝胶在设计、交联机制和生物功能方面的最新进展。特别关注它们在原位凝胶系统、癌症治疗、肌肉骨骼修复和神经再生中的作用。还讨论了与机械强度、降解控制和临床转化相关的挑战，以及可扩展制造和监管批准的未来前景。
