青蒿素类药物治疗甲硝唑耐药贾第虫病。
Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis.
机构信息
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Infect Dis. 2022 May 16;225(10):1773-1776. doi: 10.1093/infdis/jiab287.
BACKGROUND
Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis.
METHODS
Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008-2020, were retrospectively identified.
RESULTS
Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy) and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded.
CONCLUSIONS
Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability.
背景
关于氯喹治疗硝基咪唑类药物难治性贾第虫病的疗效和耐受性的证据有限。
方法
在 2008 年至 2020 年期间，回顾性确定了 87 例经微生物学（显微镜检查和/或 PCR）证实的 2 个疗程后治疗失败的硝基咪唑类药物难治性贾第虫病病例。
结果
在 87 例患者中，54 例（62%）曾去过印度。54 例（62%）使用了氯喹；51 例接受了单药治疗，3 例与甲硝唑联合治疗。只有 3 例在氯喹治疗后粪便样本仍呈阳性且症状持续（寄生虫学疗效 94%），所有患者在第二次治疗后均治愈。1 例（1.9%）记录到轻度不良反应。
结论
氯喹治疗硝基咪唑类药物难治性贾第虫病有效，耐受性良好。
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