Pedrinolla Anna, Magliozzi Roberta, Colosio Alessandro L, Danese Elisa, Gelati Matteo, Rossi Stefania, Pogliaghi Silvia, Calabrese Massimiliano, Muti Ettore, Cè Emiliano, Longo Stefano, Esposito Fabio, Lippi Giuseppe, Schena Federico, Venturelli Massimo
Department of Neurosciences, Biomedicine, and Movement Science, Section of Movement Science, University of Verona, Italy.
Department of Life and Reproduction Sciences, Laboratory of Clinical Biochemistry, University of Verona, Italy.
J Gerontol A Biol Sci Med Sci. 2022 Mar 3;77(3):588-596. doi: 10.1093/gerona/glab148.
Vascular dysfunction and associated disorders are major side effects of chronic bed rest, yet passive mobilization as a potential treatment has only been theorized so far. This study investigated the effects of passive mobilization treatment on vascular function in older, chronically bedridden people.
The study sample was 45 chronically bedridden people of advanced age (mean age: 87 years; 56% female; mean bed rest: 4 years) randomly assigned to a treatment (n = 23) or a control group (CTRL, n = 22). The treatment group received passive mobilization twice daily (30 minutes, 5 times/wk) for 4 weeks. A kinesiologist performed passive mobilization by passive knee flexion/extension at 1 Hz in one leg (treated leg [T-leg] vs control leg [Ctrl-leg]). The CTRL group received routine treatment. The primary outcome was changes in peak blood flow (∆peak) as measured with the single passive leg movement test at the common femoral artery.
∆Peak was increased in both legs in the Treatment group (+90.9 mL/min, p < .001, in T-leg and +25.7 mL/min, p = .039 in Ctrl-leg). No difference in peak blood flow after routine treatment was found in the CTRL group.
Improvement in vascular function after 4 weeks of passive mobilization was recorded in the treatment group. Passive mobilization may be advantageously included in standard clinical practice as an effective strategy to treat vascular dysfunction in persons with severely limited mobility.
血管功能障碍及相关疾病是长期卧床休息的主要副作用，但迄今为止，被动活动作为一种潜在治疗方法仅存在于理论层面。本研究调查了被动活动治疗对老年长期卧床患者血管功能的影响。
研究样本为45名高龄长期卧床患者（平均年龄：87岁；56%为女性；平均卧床时间：4年），随机分为治疗组（n = 23）和对照组（CTRL，n = 22）。治疗组每天接受两次被动活动（每次30分钟，每周5次），持续4周。一名运动治疗师通过在一条腿上以1赫兹的频率进行被动膝关节屈伸来实施被动活动（治疗腿[T腿]与对照腿[Ctrl腿]）。对照组接受常规治疗。主要结局指标是通过股总动脉单腿被动运动试验测量的峰值血流变化（∆峰值）。
治疗组双腿的∆峰值均增加（T腿增加90.9毫升/分钟，p <.001；Ctrl腿增加25.7毫升/分钟，p =.039）。对照组在常规治疗后峰值血流无差异。
治疗组在被动活动4周后血管功能得到改善。被动活动可作为一种有效策略有利地纳入标准临床实践，用于治疗活动严重受限者的血管功能障碍。
