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同期右侧肾切除术联合原位肝肾联合移植——一种治疗常染色体显性遗传性多囊肾病的患者的替代方法。

Simultaneous right-sided nephrectomy with orthotopic liver and kidney transplantation-An alternative method for patients with autosomal dominant polycystic liver and kidney disease.

机构信息

Department of General, Visceral and Vascular Surgery, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.

Research Programme "Else Kröner-Forschungskolleg AntiAge", University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.

出版信息

Langenbecks Arch Surg. 2021 Sep;406(6):2107-2115. doi: 10.1007/s00423-021-02206-9. Epub 2021 May 26.

DOI:10.1007/s00423-021-02206-9
PMID:34036408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8481182/
Abstract

PURPOSE

In patients suffering from autosomal dominant polycystic liver and kidney disease (ADPLKD), combined organ transplantation often poses a technical challenge due to the large volume of both organs. To simplify the transplantation procedure by improving the exposure of anatomical structures, we introduce a novel surgical technique of orthotopic liver and kidney transplantation.

METHODS

The modified simultaneous liver and kidney transplantation technique via a right-sided L-incision included three steps: (1) right-sided nephrectomy in the recipient followed by (2) orthotopic liver transplantation in cava replacement technique and (3) the orthotopic kidney transplantation with arterial reconstruction to the right common iliac artery.

RESULTS

In total, seven patients with ADPLKD were transplanted by using the modified transplantation technique. The mean operation time was 342.43 min (±68.77). Postoperative patients were treated for 6.28 days (±2.50) in the intensive care unit and were discharged from the surgical ward approximately 28 days (±5.66) after the operation with normal graft function. Complications associated with the use of the modified technique, such as bleeding, anastomotic stenosis, biloma, or urinoma, did not occur.

CONCLUSION

Modified simultaneous liver and kidney transplantation is a safe alternative for patients with ADPLKD. By combining right-sided nephrectomy and orthotopic graft transplantation, the approach optimizes the exposure of anatomical structures and simplifies the transplantation procedure. Additionally, the modified transplantation technique does not require a particular organ explantation procedure and can be applied for all liver and kidney grafts.

摘要

目的

在常染色体显性遗传多囊肾病(ADPLKD)患者中,由于两个器官的体积都很大,联合器官移植常常带来技术挑战。为了通过改善解剖结构的显露来简化移植过程,我们引入了一种新的原位肝肾联合移植技术。

方法

通过右侧 L 形切口的改良同期肝肾联合移植技术包括三个步骤:(1)受者右侧肾切除术,随后(2)腔静脉替代技术原位肝移植,以及(3)将动脉重建至右侧髂总动脉的原位肾移植。

结果

共 7 例 ADPLKD 患者采用改良移植技术进行移植。平均手术时间为 342.43 分钟(±68.77)。术后患者在重症监护病房接受治疗 6.28 天(±2.50),术后约 28 天(±5.66)出院,移植物功能正常。未发生与改良技术相关的并发症,如出血、吻合口狭窄、胆漏或尿漏。

结论

改良同期肝肾联合移植是 ADPLKD 患者的一种安全选择。通过结合右侧肾切除术和原位移植物移植,该方法优化了解剖结构的显露,简化了移植过程。此外,改良的移植技术不需要特定的器官取出程序,可适用于所有肝、肾移植物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/ffcc19d0f5b7/423_2021_2206_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/dc382e9c67c3/423_2021_2206_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/90edcb38aa25/423_2021_2206_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/ffcc19d0f5b7/423_2021_2206_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/dc382e9c67c3/423_2021_2206_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/90edcb38aa25/423_2021_2206_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d681/8481182/ffcc19d0f5b7/423_2021_2206_Fig3_HTML.jpg

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2
Outcomes of en bloc simultaneous liver-kidney transplantation compared to the traditional technique.整块同时肝-肾移植与传统技术的结果比较。
Am J Transplant. 2020 Apr;20(4):1181-1187. doi: 10.1111/ajt.15655. Epub 2019 Nov 6.
3
Delayed kidney transplantation in combined liver-kidney transplantation for polycystic liver and kidney disease.
多囊肝肾病肝肾联合移植中的延迟肾移植
Transpl Int. 2019 Dec;32(12):1336-1338. doi: 10.1111/tri.13537. Epub 2019 Oct 17.
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Int J Surg Case Rep. 2018;53:13-16. doi: 10.1016/j.ijscr.2018.10.002. Epub 2018 Oct 8.
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Total Kidney Volume and Autosomal Dominant Polycystic Kidney Disease: A Long-Standing Relationship.总肾体积与常染色体显性遗传性多囊肾病:长期存在的关系
Am J Nephrol. 2018;48(1):65-66. doi: 10.1159/000491026. Epub 2018 Aug 2.
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Combined Dual-Kidney Liver Transplantation in the United States: A Review of United Network for Organ Sharing/Organ Procurement and Transplantation Network Data Between 2002 and 2012.美国联合肝肾移植:2002 年至 2012 年间美国器官共享联合网络/器官获取和移植网络数据回顾。
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