Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi, South Korea.
Neurourol Urodyn. 2021 Aug;40(6):1569-1575. doi: 10.1002/nau.24711. Epub 2021 May 26.
To investigate the association of nocturia with the prevalence of cardiovascular disease (CVD) using the National Health and Nutrition Examination Survey (NHANES) data.
Among the 40 790 individuals who participated in NHANES from 2005 to 2012, 14 114 adults were analyzed in this study. A participant was considered to have nocturia if they have two or more voiding episodes nightly. In addition, participants with nocturia more than four times in a day were considered to have severe nocturia. A multivariate logistic regression analysis with adjustment for confounding variables, including age, sex, race, body mass index (BMI), smoking status, alcohol consumption, sleeping time, dyslipidemia, hypertension, and diabetes mellitus was performed with 1:1 propensity score matching (PSM).
Nocturia occurred in 4610 individuals (32.7%). The prevalence of CVD was significantly higher in men, older individuals, those with higher BMI, smokers, and those with diabetes, hypertension, and hyperlipidemia. There was also a significantly higher prevalence of nocturia in the participants with CVD. Multivariate analysis showed that odds ratios (ORs) of mild and severe nocturia for CVD were 1.23 (95% confidence interval [CI]: 1.08-1.39) and 1.74 (95% CI: 1.39-2.17), respectively. After 1:1 PSM, the ORs of mild and severe nocturia were 1.27 (95% CI: 1.10-1.48) and 1.73 (95% CI: 1.33-2.26), respectively, showing statistical significance.
Data from the NHANES indicate that CVD was significantly associated with the prevalence of nocturia, after taking major confounding factors into account. Furthermore, the risk for CVD increases with increasing nocturia severity.
利用国家健康与营养调查（NHANES）数据，研究夜尿症与心血管疾病（CVD）患病率之间的关系。
在 2005 年至 2012 年参加 NHANES 的 40790 名个体中，本研究分析了 14114 名成年人。如果参与者每晚有两次或更多次排尿，则认为他们患有夜尿症。此外，如果参与者每天夜间排尿超过 4 次，则认为他们患有严重夜尿症。对年龄、性别、种族、体重指数（BMI）、吸烟状况、饮酒量、睡眠时间、血脂异常、高血压和糖尿病等混杂因素进行调整后，采用 1:1 倾向评分匹配（PSM）进行多变量逻辑回归分析。
4610 名个体（32.7%）出现夜尿症。男性、年龄较大、BMI 较高、吸烟者以及患有糖尿病、高血压和血脂异常的个体中 CVD 的患病率显著较高。患有 CVD 的参与者中夜尿症的患病率也显著较高。多变量分析显示，CVD 患者发生轻度和重度夜尿症的比值比（ORs）分别为 1.23（95%置信区间 [CI]：1.08-1.39）和 1.74（95% CI：1.39-2.17）。经过 1:1 PSM 后，轻度和重度夜尿症的 ORs 分别为 1.27（95% CI：1.10-1.48）和 1.73（95% CI：1.33-2.26），差异有统计学意义。
NHANES 的数据表明，在考虑主要混杂因素后，CVD 与夜尿症的患病率显著相关。此外，随着夜尿症严重程度的增加，CVD 的风险也会增加。
