Madani Ali Hamidi, Bateni Bahador Heidari, Pourrajabi Aseme, Leyli Ehsan Kazemnezhad, Madani Mohammad Hamidi
Urology Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Int Urol Nephrol. 2025 Mar;57(3):709-713. doi: 10.1007/s11255-024-04241-z. Epub 2024 Oct 23.
Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Recently, non-classical risk factors for cardiovascular disease, such as lower urinary tract symptoms (LUTS), have gained attention. Both CVD and LUTS are prevalent among aging populations and share common vascular risk factors. The purpose of this study was to investigate the potential relationship between Atherosclerotic Cardiovascular Disease risk and functional bladder capacity among men with LUTS.
This study was conducted on 86 men aged 40-79 with complaints of LUTS who were asked for digital rectal examinations, blood tests on serum total cholesterol and high-density lipoprotein (HDL), and mid-stream urine tests for microscopy and culture. For evaluating patients' LUTS, a 24-h voiding diary was asked. The atherosclerotic cardiovascular diseases (ASCVD) score comprises the patient's current age, sex, race, diabetes mellitus status, smoking status, hypertension status, systolic and diastolic blood pressure, total cholesterol, and HDL levels.
According to the ASCVD score, 46 and 40 patients were categorized as low and high risks for cardiovascular diseases, respectively. Based on the FBC, 47 patients had decreased FBC and the rest were normal. According to logistic regression, it was determined that age can be considered a predictive variable for decreased FBC and the lower FBC can be considered as a predictive factor in the high-risk group for cardiovascular diseases (p = 0.002).
It seems that decreased FBC is related to a higher predicted cardiovascular event rate in men with LUTS and could be considered a predictor of ASCVD risk.
心血管疾病（CVD）是全球主要的死亡原因之一。最近，心血管疾病的非经典危险因素，如下尿路症状（LUTS），受到了关注。CVD和LUTS在老年人群中都很普遍，并且有共同的血管危险因素。本研究的目的是调查患有LUTS的男性中动脉粥样硬化性心血管疾病风险与功能性膀胱容量之间的潜在关系。
本研究对86名年龄在40 - 79岁、有LUTS症状的男性进行，这些男性接受了直肠指检、血清总胆固醇和高密度脂蛋白（HDL）血液检测，以及用于显微镜检查和培养的中段尿检测。为了评估患者的LUTS，要求填写一份为期24小时的排尿日记。动脉粥样硬化性心血管疾病（ASCVD）评分包括患者的当前年龄、性别、种族、糖尿病状态、吸烟状态、高血压状态、收缩压和舒张压、总胆固醇以及HDL水平。
根据ASCVD评分，分别有46名和40名患者被归类为心血管疾病低风险和高风险。基于功能性膀胱容量（FBC），47名患者的FBC降低，其余患者正常。根据逻辑回归分析，确定年龄可被视为FBC降低的预测变量，而较低的FBC可被视为心血管疾病高风险组的预测因素（p = 0.002）。
似乎FBC降低与患有LUTS的男性中较高的预测心血管事件发生率相关，并且可被视为ASCVD风险的预测指标。
