Zhang Xiao, Hong Feng, Qin Zixiu, Liu Leilei, Yang Jun, Tang Xuejie, Li Xi, Zhang Jiangping, Luo Peng
School of Public Health, Guizhou Medical University, Guiyang, China.
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Diabetes Metab Res Rev. 2022 Jan;38(1):e3475. doi: 10.1002/dmrr.3475. Epub 2021 Jun 7.
High resting heart rate (RHR), one abnormal manifestation of autonomic nervous system, is associated with metabolic disorders. However, the association between RHR and metabolic syndrome (MetS) and its components remains controversial. We aimed to explore the link between these two parameters.
The study included 6589 Dong adults (1434 cases of MetS) from the cross-sectional survey of the China Multi-Ethnic Cohort Study. Logistic regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) and assess the association between RHR and MetS, clustered metabolic risk, and MetS components. Restricted cubic splines model was used to evaluate the dose response association.
A positive association existed between RHR and MetS, and people in the highest RHR quartile had a higher MetS risk (OR 1.75 [95% CI 1.42-2.15]) than those in the lowest quartile. The clustered metabolic risk associated with RHR (p < 0.05). Furthermore, RHR was related to elevated blood pressure (BP), elevated triglycerides (TG) and elevated fasting plasma glucose (FPG); the ORs (95% CIs) for the highest versus lowest RHR quartile were 2.06 (1.75-2.43), 1.37 (1.17-1.62) and 2.53 (2.04-3.14), respectively. Similar results were found in sensitivity and subgroup analyses. Also, non-linear dose response association existed between RHR and MetS and elevated levels of BP, TG and FPG (p < 0.001).
RHR was related to increased risk of MetS, three MetS components (elevated BP, elevated TG and elevated FPG) and the clustered metabolic risk. RHR may be a useful indicator for MetS.
静息心率（RHR）增高是自主神经系统的一种异常表现，与代谢紊乱相关。然而，RHR与代谢综合征（MetS）及其组分之间的关联仍存在争议。我们旨在探究这两个参数之间的联系。
本研究纳入了中国多民族队列研究横断面调查中的6589名侗族成年人（1434例MetS患者）。采用逻辑回归模型计算比值比（OR）和95%置信区间（CI），并评估RHR与MetS、聚集性代谢风险及MetS组分之间的关联。使用受限立方样条模型评估剂量反应关联。
RHR与MetS之间存在正相关，RHR最高四分位数组的人群患MetS的风险（OR 1.75 [95% CI 1.42 - 2.15]）高于最低四分位数组。RHR与聚集性代谢风险相关（p < 0.05）。此外，RHR与血压（BP）升高、甘油三酯（TG）升高和空腹血糖（FPG）升高有关；RHR最高四分位数组与最低四分位数组相比，OR（95% CI）分别为2.06（1.75 - 2.43）、1.37（1.17 - 1.62）和2.53（2.04 - 3.14）。在敏感性分析和亚组分析中发现了类似结果。此外，RHR与MetS以及BP、TG和FPG水平升高之间存在非线性剂量反应关联（p < 0.001）。
RHR与MetS风险增加、三种MetS组分（BP升高、TG升高和FPG升高）以及聚集性代谢风险相关。RHR可能是MetS的一个有用指标。
