一种简单可行的原子精度生物素化 Cu(i) 配合物，用于肿瘤靶向化学动力学治疗。
A simple and feasible atom-precise biotinylated Cu(i) complex for tumor-targeted chemodynamic therapy.
机构信息
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.
出版信息
Chem Commun (Camb). 2021 Jun 21;57(49):6046-6049. doi: 10.1039/d1cc00515d. Epub 2021 May 25.
PMID:34036986
Abstract
A simple and feasible atom-precise biotinylated Cu(i) complex, which can catalyze HO overexpressed commonly in the tumor microenvironment to produce ˙OH through a Fenton-like reaction, was prepared and employed as an effective agent for tumor-targeted chemodynamic therapy.
摘要
一种简单可行的原子精度生物素化 Cu(i) 配合物，能够通过类芬顿反应催化肿瘤微环境中过度表达的 HO 产生˙OH，被制备并用作肿瘤靶向化学动力学治疗的有效试剂。
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