Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials, School of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010000, P.R. China.
Dalton Trans. 2021 Nov 9;50(43):15870-15877. doi: 10.1039/d1dt03110d.
Nanocatalytic cancer therapy based on chemodynamic therapy, which converts hydrogen peroxide (HO) into toxic reactive oxygen species the Fenton-like reaction, is regarded as a promising therapeutic strategy due to its specific response toward the tumor microenvironment (TME). However, the HO concentration in TME (100 μM to 1 mM) is insufficient and introducing enough HO or HO-generating agents is challenging. In view of this, we report a drug delivery system, CaO/DOX@Cu/ZIF-8@HA (CDZH), which is capable of targeted HO self-supply and exhibits outstanding chemo/chemodynamic synergetic therapy capability. CaO/DOX@Cu/ZIF-8@HA is synthesized by fabricating biodegradable Cu/ZIF-8 shell-encapsulated CaO nanoparticles, loading chemotherapy drug doxorubicin, and coating a hyaluronic acid shell. In an acidic tumor microenvironment, the CDZH nanostructures targeted the release of doxorubicin, Cu, and CaO. Doxorubicin affects chemotherapy and bioimaging, and CaO supplies HO through a Cu-Fenton-like reaction to generate hydroxyl radicals with high oxidation activity for chemodynamic therapy. In brief, the drug delivery system combined targeted HO self-supply and targeted bioimaging possess the potential of an efficient synergistic strategy for chemodynamic therapy and chemotherapy.
基于化学动力学治疗的纳米催化癌症治疗，通过芬顿样反应将过氧化氢 (HO) 转化为有毒的活性氧，被认为是一种很有前途的治疗策略，因为它对肿瘤微环境 (TME) 具有特异性反应。然而，TME 中的 HO 浓度（100 μM 至 1 mM）不足，引入足够的 HO 或产生 HO 的试剂具有挑战性。有鉴于此，我们报告了一种药物输送系统，CaO/DOX@Cu/ZIF-8@HA（CDZH），它能够靶向自我供应 HO，并表现出出色的化疗/化学动力学协同治疗能力。CaO/DOX@Cu/ZIF-8@HA 通过构建可生物降解的 Cu/ZIF-8 壳包裹的 CaO 纳米粒子、负载化疗药物阿霉素并涂覆透明质酸壳来合成。在酸性肿瘤微环境中，CDZH 纳米结构靶向释放阿霉素、Cu 和 CaO。阿霉素影响化疗和生物成像，而 CaO 通过 Cu-Fenton 样反应提供 HO，生成具有高氧化活性的羟基自由基用于化学动力学治疗。简而言之，该药物输送系统结合了靶向 HO 自我供应和靶向生物成像，具有高效协同化学动力学治疗和化疗的潜力。
