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纤维蛋白生物聚合物密封剂与跟腱修复水疗运动的关联。

Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair.

机构信息

MSc. Universidade Brasil - Scientific and Technological Institute - Sao Paulo (SP), Brazil.

PhD. Universidade Brasil - Scientific and Technological Institute - Sao Paulo (SP), Brazil.

出版信息

Acta Cir Bras. 2021 May 21;36(4):e360407. doi: 10.1590/ACB360407. eCollection 2021.

DOI:10.1590/ACB360407
PMID:34037082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8148814/
Abstract

PURPOSE

The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair.

METHODS

Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection.

RESULTS

The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn't induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site.

CONCLUSIONS

Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery.

摘要

目的

本研究旨在分析纤维蛋白生物聚合物密封剂（FS）联合或不联合水疗（AE）对跟腱修复的影响。

方法

将 44 只雌性 Wistar 大鼠随机分为 4 个实验组：损伤对照组（L）、损伤+FS 组（LS）、损伤+AE 组（LE）和损伤+FS 联合 AE 组（LSE）。部分跟腱切断后 7、14 和 21 天，评估水肿体积（EV）、胶原比例和组织病理学分析。

结果

与 L 组相比，所有治疗组在 7 天和 21 天时 EV 均有统计学降低。LS 和 LSE 在治疗 21 天后 EV 降低最明显。FS 组在组织病理学分析中未诱导组织坏死或感染。在 FS 组中，观察到腱部分横断区的成纤维细胞增殖、肉芽组织和胶原形成。LSE 显示出更多的肉芽组织，并增加了损伤部位的胶原沉积。

结论

我们的数据表明，异体纤维蛋白生物聚合物密封剂联合水疗方案的治疗潜力值得进一步探索，因为它可能刺激再生阶段并优化跟腱的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/6c62d8e2fa6a/1678-2674-acb-36-4-e360407-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/e353dfcf2e06/1678-2674-acb-36-4-e360407-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/adba87445999/1678-2674-acb-36-4-e360407-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/d2b8c9c23d7b/1678-2674-acb-36-4-e360407-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/6c62d8e2fa6a/1678-2674-acb-36-4-e360407-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/e353dfcf2e06/1678-2674-acb-36-4-e360407-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/adba87445999/1678-2674-acb-36-4-e360407-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/d2b8c9c23d7b/1678-2674-acb-36-4-e360407-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e8/8148814/6c62d8e2fa6a/1678-2674-acb-36-4-e360407-gf04.jpg

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