Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina, Universidade de São Paulo - USP - São Paulo (SP), Brasil.
Codas. 2021 May 21;33(2):e20190207. doi: 10.1590/2317-1782/20202019207. eCollection 2021.
To identify and analyze what are the characteristic findings of Cortical Auditory Evoked Potentials (CAEP) in children and / or adolescents with Autism Spectrum Disorder (ASD) compared to typical development, through a systematic literature review.
Based on the formulation of a research question, a bibliographic survey was carried out in seven databases (Web of Science, Pubmed, Cochrane Library, Lilacs, Scielo, Science Direct, and Google Sholar), with the following descriptors: autism spectrum disorder (transtorno do espectro autista), autistic disorder (transtorno autístico), evoked potentials, auditory (potenciais evocados auditivos), event related potentials, P300 (potencial evocado P300) e child (criança). This review was registered in Prospero, under number 118751.
Were selected articles published, without language limitation, between 2007 and 2019.
The characteristics of the latency and amplitude aspects of the P1, N1, P2, N2 and P3 components present in the CAEP.
193 studies were located; however, 15 original articles were included the inclusion criteria for this study. Although it has not been possible to identify any pattern of response for the P1, N1, P2 and N2 components, the results of the selected studies have demonstrated that individuals with ASD may present a decrease in amplitude and increase in latency of the P3 component.
Individuals with ASD may present different responses to the components of the CAEP, and the decrease of the amplitude and increase of the latency of the P3 component were the most common characteristics.
通过系统的文献回顾，确定并分析与典型发育相比，自闭症谱系障碍（ASD）儿童和/或青少年的皮质听觉诱发电位（CAEP）的特征表现。
根据研究问题的制定，在七个数据库（Web of Science、Pubmed、Cochrane Library、Lilacs、Scielo、Science Direct 和 Google Scholar）中进行了文献调查，使用了以下描述词：自闭症谱系障碍（transtorno do espectro autista）、自闭症（transtorno autístico）、诱发电位、听觉（potenciais evocados auditivos）、事件相关电位、P300（potencial evocado P300）和儿童（criança）。本综述在 Prospero 中注册，编号为 118751。
选择发表的文章，无语言限制，发表时间为 2007 年至 2019 年。
对 CAEP 中 P1、N1、P2、N2 和 P3 成分的潜伏期和振幅特征进行分析。
共定位到 193 项研究，但符合纳入标准的仅有 15 项原始研究。虽然尚未确定 P1、N1、P2 和 N2 成分的任何反应模式，但所选研究的结果表明，ASD 个体可能表现出 P3 成分的振幅降低和潜伏期延长。
ASD 个体可能对 CAEP 的各个成分表现出不同的反应，而 P3 成分的振幅降低和潜伏期延长是最常见的特征。
