阿尔茨海默病病理学与衰老内在功能记忆网络的去分化有关。
Alzheimer's Pathology Is Associated with Dedifferentiation of Intrinsic Functional Memory Networks in Aging.
机构信息
Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
出版信息
Cereb Cortex. 2021 Aug 26;31(10):4781-4793. doi: 10.1093/cercor/bhab122.
In presymptomatic Alzheimer's disease (AD), beta-amyloid plaques (Aβ) and tau tangles accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic memory decline. Here, we tested whether age-related changes in the segregation of the brain's intrinsic functional episodic memory networks-anterior-temporal (AT) and posterior-medial (PM) networks-are associated with the accumulation of Aβ, tau, and memory decline using fMRI and PET. We found that AT and PM networks were less segregated in older than that in younger adults and this reduced specialization was associated with more tau and Aβ in the same regions. The effect of network dedifferentiation on memory depended on the amount of Aβ and tau, with low segregation and pathology associated with better performance at baseline and low segregation and high pathology related to worse performance over time. This pattern suggests a compensation phase followed by a degenerative phase in the early, preclinical phase of AD.
在无症状阿尔茨海默病（AD）中，β-淀粉样斑块（Aβ）和tau 缠结在大脑内以不同的时空模式积累，与情景记忆下降密切相关。在这里，我们使用 fMRI 和 PET 测试了大脑内在功能情景记忆网络（前颞叶（AT）和后内侧（PM）网络）的分离随年龄的变化是否与 Aβ、tau 和记忆下降的积累有关。我们发现，与年轻成年人相比，老年人的 AT 和 PM 网络的分离程度较低，这种去分化与同一区域内更多的 tau 和 Aβ 有关。网络去分化对记忆的影响取决于 Aβ 和 tau 的数量，低分离和低病理与基线时的更好表现相关，而低分离和高病理与随时间的更差表现相关。这种模式表明在 AD 的早期、临床前阶段存在补偿阶段，随后是退行性阶段。
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