Department of Dermatology, Institute of Dermatology and Hospital of Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Int J Dermatol. 2021 Dec;60(12):1441-1448. doi: 10.1111/ijd.15589. Epub 2021 May 26.
Bullous pemphigoid (BP) is a common autoimmune bullous disease which mainly affects the elderly. The incidence of BP is gradually increasing and associated with high mortality. This disease is clinically characterized by intensely pruritic and widespread bullous lesions. Alternative therapy options for pruritus in patients with BP are limited primarily because pathophysiological mechanisms of itching in BP are still unclear. This review aims to explain crucial concepts of the pathogenesis of pruritus in BP. Vital findings in recent years will be summarized, and cofactors of the pathogenesis of pruritus will be discussed in detail. We will summarize knowledge on pathogenic factors in the immunologic level conducing to skin pruritus in BP.
大疱性类天疱疮（BP）是一种常见的自身免疫性大疱性疾病，主要影响老年人。BP 的发病率逐渐增加，且与高死亡率相关。该病临床上表现为剧烈瘙痒和广泛的大疱性皮损。BP 患者瘙痒的替代治疗选择有限，主要是因为 BP 瘙痒的病理生理机制仍不清楚。本文旨在阐述 BP 瘙痒发病机制的关键概念。本文将总结近年来的重要发现，并详细讨论瘙痒发病机制的协同因素。我们将总结导致 BP 皮肤瘙痒的免疫水平发病因素的相关知识。
