Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland.
Department of Neurology and Stroke, Medical University of Lodz, 90-419 Lodz, Poland.
Medicina (Kaunas). 2024 Oct 16;60(10):1701. doi: 10.3390/medicina60101701.
: Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting mainly elderly patients. Still, little is known about the pathogenesis of pruritus in BP or the factors that affect the clinical course of the disease. This study aimed to evaluate the factors influencing the clinical course of BP among older patients. : A retrospective analysis of medical records of 55 patients with BP hospitalized in the dermatology department in 2015-2021 was conducted. The study focused on preliminary diagnosis, medical history, clinical examination (characteristics and location of cutaneous changes), laboratory investigation, and direct and indirect immunofluorescence. : Analysis of laboratory results in combination with the clinical course of BP showed that red blood cell count, hemoglobin, and hematocrit values were negatively associated with a risk of erosions and erythema, while MCHC values were positively correlated with a risk of associated pruritus. A correlation was found between neurological diseases and an increased risk of erosions. : We have shown that age and neurological conditions, including stroke, affect the clinical course of BP. Further studies on a larger group of patients should be conducted to investigate the different factors affecting the clinical aspect of BP and to understand the relationship between them.
大疱性类天疱疮（BP）是最常见的自身免疫性水疱性疾病，主要影响老年患者。然而，对于 BP 瘙痒的发病机制或影响疾病临床过程的因素知之甚少。本研究旨在评估影响老年 BP 患者临床过程的因素。
对 2015 年至 2021 年在皮肤科住院的 55 例 BP 患者的病历进行回顾性分析。研究重点是初步诊断、病史、临床检查（皮肤变化的特征和部位）、实验室检查以及直接和间接免疫荧光。
对实验室结果进行分析，并结合 BP 的临床过程，结果表明红细胞计数、血红蛋白和血细胞比容值与糜烂和红斑的风险呈负相关，而 MCHC 值与瘙痒的风险呈正相关。还发现神经系统疾病与糜烂风险增加之间存在相关性。
我们已经表明，年龄和包括中风在内的神经系统疾病会影响 BP 的临床过程。应在更大的患者群体中进行进一步的研究，以调查影响 BP 临床方面的不同因素，并了解它们之间的关系。
