Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne.
Developmental Neuropsychiatry Program, Royal Children's Hospital, Parkville, VIC, Australia.
J Nerv Ment Dis. 2021 Jun 1;209(6):454-458. doi: 10.1097/NMD.0000000000001293.
The specific relationships between impulsiveness, inattention, sad, low mood, and irritability have not been systematically examined in young people with major depressive disorder with and without persistent depressive disorder. The relationships are important to clarify because these symptom dimensions may increase suicidal risk in children and adolescents with these depressive disorders. A total of 313 medication-naive young people (aged 6-16 years) with active major depressive disorder (MDD) alone, persistent depressive disorder (DD) alone, and comorbid MDD and DD were identified. "Inattention," "sad/unhappy," and "irritable" mood were identified by parent standardized questionnaire. Standard multiple regression was used to investigate how well inattention, sad/unhappy, and irritable mood predict impulsiveness. Inattention (32% of the variance, increased) and irritable mood (5% of the variance, increased) both made independent significant contributions to impulsiveness, whereas sad/unhappy mood did not. Decreasing irritability via more targeted and comprehensive management approaches may ameliorate impulsiveness in young people with these depressive disorders.
在伴有或不伴有持续性抑郁障碍的青少年重度抑郁症患者中，冲动、注意力不集中、悲伤、情绪低落和易怒之间的具体关系尚未得到系统研究。这些关系很重要，因为这些症状维度可能会增加这些患有抑郁症的儿童和青少年的自杀风险。共有 313 名未经药物治疗的年轻患者（年龄在 6-16 岁）患有活动性重度抑郁症（MDD）、持续性抑郁障碍（DD）或 MDD 和 DD 共病。通过家长标准化问卷确定了“注意力不集中”、“悲伤/不开心”和“易怒”的情绪。采用标准多元回归分析来研究注意力不集中、悲伤/不开心和易怒情绪对冲动的预测程度。注意力不集中（占 32%的方差，增加）和易怒情绪（占 5%的方差，增加）均对冲动产生独立的显著影响，而悲伤/不开心情绪则没有。通过更有针对性和全面的管理方法来降低易怒情绪可能会改善这些患有抑郁障碍的年轻人的冲动。
