Grupo de Investigación en Ciencias de la Educación y de la Salud (ICES), UNISANGIL, San Gil, Colombia.
Instituto Colombiano de Medicina Tropical-Universidad CES, Medellín, Colombia.
Pathog Dis. 2021 Jun 8;79(5). doi: 10.1093/femspd/ftab028.
Cutaneous leishmaniasis (CL) is an infectious and neglected disease caused by parasites of the genus Leishmania, which produces a wide spectrum of cutaneous manifestations. CL research has shown that the innate immune activity of cells such as neutrophils, natural killers, macrophages, dendritic cells and the complement system are capable of controlling this infection. However, Leishmania can also modulate the immune activity of these cells to promote its own survival and proliferation at the intracellular level. This review discusses the role of the innate immune response in the control and spread of this infection.
皮肤利什曼病（CL）是一种由利什曼原虫属寄生虫引起的传染性和被忽视的疾病，可产生广泛的皮肤表现。CL 研究表明，中性粒细胞、自然杀伤细胞、巨噬细胞、树突状细胞和补体系统等细胞的固有免疫活性能够控制这种感染。然而，利什曼原虫也可以调节这些细胞的免疫活性，以促进其在细胞内水平的存活和增殖。本文综述了固有免疫反应在控制和传播这种感染中的作用。
