Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC, Av. dos Estados, 5001, Bairro Bangú, Santo André, SP, Brasil.
Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, Vila Clementino, São Paulo, SP, Brasil.
Photodiagnosis Photodyn Ther. 2021 Sep;35:102343. doi: 10.1016/j.pdpdt.2021.102343. Epub 2021 May 24.
Hypericin is considered a potent photosensitizer for use in antitumor and antimicrobial photodynamic therapy (PDT). This review presents the primary biological results obtained with hypericin in photodynamic therapy applications, such as photodynamic cancer treatment, photoinactivation of microorganisms (PDI), tissue scarring, and photo diagnosis. We present a compilation of in vitro results that have been published thus far; for these studies, we highlight the hypericin concentration, light dose, and other experimental conditions to evaluate the efficiency of photodynamic treatment like cell death, cell viability, or cell proliferation. The results indicate that different hypericin phototoxicity levels can be observed according to the specific light dose and concentration. Furthermore, it was shown that cellular localization and cell death mechanisms (apoptosis and necrosis) are dependent on the cell type.
金丝桃素被认为是一种有效的光敏剂，可用于抗肿瘤和抗菌光动力疗法（PDT）。本文综述了金丝桃素在光动力治疗应用中的主要生物学研究结果，如光动力癌症治疗、微生物光灭活（PDI）、组织瘢痕形成和光诊断。我们汇集了迄今为止已发表的体外研究结果；对于这些研究，我们强调了金丝桃素浓度、光剂量和其他实验条件，以评估光动力治疗的效率，如细胞死亡、细胞活力或细胞增殖。结果表明，根据特定的光剂量和浓度，可以观察到不同的金丝桃素光毒性水平。此外，还表明细胞定位和细胞死亡机制（凋亡和坏死）取决于细胞类型。
