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高危患者中广泛 COVID-19 相关凝血功能障碍的迟发性表现。

Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient.

机构信息

Medical Oncology, East Tennessee State University, Johnson City, Tennessee, USA.

Internal Medicine, East Tennessee State University, Johnson City, Tennessee, USA

出版信息

BMJ Case Rep. 2021 May 26;14(5):e242921. doi: 10.1136/bcr-2021-242921.

Abstract

COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hodgkin's lymphoma, who was diagnosed with COVID-19 infection prior to initiating chemotherapy. Two months after resolution of symptoms and testing negative for COVID-19, she presented with multiple acute thromboembolic complications of the infection, including bilateral jugular venous thrombosis, right atrial clot and arterial emboli in the brain resulting in cerebrovascular injury. These were thought to be delayed manifestations of the systemic coagulopathy secondary to infection. Also, some of these thromboembolic phenomena occurred while the patient was on anticoagulation, which emphasises the extensive hyperinflammatory state caused by the virus. This case highlights the importance of thromboprophylaxis especially in high-risk patients with this infection.

摘要

新型冠状病毒肺炎是由新型冠状病毒引起的传染病。它表现为急性呼吸道疾病,但也会影响多个其他器官系统。其中一种独特的表现是涉及动脉和静脉系统的全身性凝血功能障碍。我们报告了一例 29 岁的女性霍奇金淋巴瘤患者,她在开始化疗前被诊断为 COVID-19 感染。在症状缓解和 COVID-19 检测阴性两个月后,她出现了感染引起的多种急性血栓栓塞并发症,包括双侧颈静脉血栓形成、右心房血栓和脑动脉栓塞导致的脑血管损伤。这些被认为是继发于感染的全身性凝血功能障碍的迟发性表现。此外,这些血栓栓塞现象中的一些发生在患者接受抗凝治疗期间,这强调了病毒引起的广泛炎症反应状态。本病例强调了对这种感染的高危患者进行血栓预防的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/896e/8160192/0e3adea9dd6e/bcr-2021-242921f01.jpg

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