单细胞 RNA 测序在胰腺癌中的应用。
Single-cell RNA sequencing in pancreatic cancer.
机构信息
Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Translational Molecular Pathology, The Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):451-452. doi: 10.1038/s41575-021-00471-z.
Abstract
The application of single-cell RNA sequencing platforms has generated notable insights into the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing both the neoplastic compartment and the tumour microenvironment. In this Comment, we discuss the most pertinent findings gleaned from both mouse models and human PDAC samples, as well as future opportunities.
摘要
单细胞 RNA 测序平台的应用为胰腺导管腺癌 (PDAC) 的异质性提供了重要的见解，包括肿瘤细胞和肿瘤微环境。在这篇评论中，我们讨论了从小鼠模型和人类 PDAC 样本中获得的最相关发现，以及未来的机会。
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