Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Department of Breast Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Br J Cancer. 2021 Aug;125(4):611-617. doi: 10.1038/s41416-021-01409-7. Epub 2021 May 26.
Ethnic minority women are commonly reported to have more aggressive breast cancer than White women, but there is little contemporary national evidence available.
We analysed data from the National Cancer Registration and Analysis Service on women diagnosed with invasive breast cancer during 2013-2018. Multivariable logistic regression yielded adjusted odds ratios (and 95% confidence intervals) of less favourable tumour characteristics (high stage, high grade, ER negative, Her2 positive) by ethnicity (black African, black Caribbean, Indian, Pakistani and white) in younger (30-46 years) and older (53-70 years) women.
In 24,022 women aged 30-46 at diagnosis, all ethnic minority groups apart from Indian women had a significantly greater odds of certain less favourable tumour characteristics compared to white women in fully adjusted models. In 92,555 women aged 53-70, all ethnic minorities had a significantly greater adjusted odds of several of the less favourable tumour characteristics. These differences were most marked in black African and black Caribbean women.
Ethnic minority women are at greater risk of breast cancers with less favourable characteristics, even after allowing for age and other potential confounders. These differences are greater in older than younger women, and in the Black rather than South Asian ethnic groups.
少数民族女性的乳腺癌通常比白人女性更具侵袭性，但目前几乎没有全国性的当代证据。
我们分析了 2013 年至 2018 年期间国家癌症登记和分析服务机构诊断为浸润性乳腺癌的女性的数据。多变量逻辑回归得出了按族裔（黑非洲人、黑加勒比人、印度人、巴基斯坦人和白人）在年轻（30-46 岁）和老年（53-70 岁）女性中肿瘤特征（高分期、高级别、ER 阴性、Her2 阳性）较差的调整比值比（及其 95%置信区间）。
在 24022 名诊断时年龄在 30-46 岁的女性中，除印度女性外，所有少数民族群体与白人女性相比，在完全调整的模型中，具有某些肿瘤特征较差的几率明显更高。在 92555 名年龄在 53-70 岁的女性中，所有少数民族在几种肿瘤特征较差的情况下，调整后的比值比都明显更高。这些差异在黑非洲人和黑加勒比人女性中最为明显。
即使考虑到年龄和其他潜在混杂因素，少数民族女性患某些肿瘤特征较差的乳腺癌的风险仍然更高。与年轻女性相比，老年女性的这些差异更大，与南亚族裔群体相比，黑人族裔群体的差异更大。
