基于 SEER 的分析：对侧乳腺癌风险。
The risk of contralateral breast cancer: a SEER-based analysis.
机构信息
Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
出版信息
Br J Cancer. 2021 Aug;125(4):601-610. doi: 10.1038/s41416-021-01417-7. Epub 2021 May 26.
BACKGROUND
We sought to estimate the annual risk and 25-year cumulative risk of contralateral breast cancer among women with stage 0-III unilateral breast cancer.
METHODS
We identified 812,851 women with unilateral breast cancer diagnosed between 1990 and 2015 in the SEER database and followed them for contralateral breast cancer for up to 25 years. Women with a known bilateral mastectomy were excluded. We calculated the annual risk of contralateral breast cancer by age at diagnosis, by time since diagnosis and by current age. We compared risks by ductal carcinoma in situ (DCIS) versus invasive disease, by race and by oestrogen receptor (ER) status of the first cancer.
RESULTS
There were 25,958 cases of contralateral invasive breast cancer diagnosed (3.2% of all patients). The annual risk of contralateral breast cancer over the 25-year follow-up period was 0.37% and the 25-year actuarial risk of contralateral invasive breast cancer was 9.9%. The annual risk varied to a small degree by age of diagnosis, by time elapsed since diagnosis and by current age. The 25-year actuarial risk was similar for DCIS and invasive breast cancer patients (10.1 versus 9.9%). The 25-year actuarial risk was higher for black women (12.7%) than for white women (9.7%) and was lower for women with ER-positive breast cancer (9.5%) than for women with ER-negative breast cancer (11.2%).
CONCLUSIONS
Women with unilateral breast cancer experience an annual risk of contralateral breast cancer ~0.4% per year, which persists over the 25-year follow-up period.
背景
我们旨在估计 0-III 期单侧乳腺癌女性中对侧乳腺癌的年风险和 25 年累积风险。
方法
我们在 SEER 数据库中确定了 1990 年至 2015 年间诊断为单侧乳腺癌的 812851 名女性，并对她们进行了长达 25 年的对侧乳腺癌随访。排除已知双侧乳房切除术的女性。我们按诊断时的年龄、诊断后时间和当前年龄计算对侧乳腺癌的年风险。我们通过导管原位癌（DCIS）与浸润性疾病、种族和第一癌的雌激素受体（ER）状态比较风险。
结果
诊断出 25958 例对侧浸润性乳腺癌（所有患者的 3.2%）。在 25 年的随访期间，对侧乳腺癌的年风险为 0.37%，25 年的对侧浸润性乳腺癌累积风险为 9.9%。对侧乳腺癌的年风险在一定程度上随诊断年龄、诊断后时间和当前年龄而变化。DCIS 和浸润性乳腺癌患者的 25 年累积风险相似（10.1%对 9.9%）。黑人女性（12.7%）的 25 年累积风险高于白人女性（9.7%），而 ER 阳性乳腺癌女性（9.5%）的 25 年累积风险低于 ER 阴性乳腺癌女性（11.2%）。
结论
单侧乳腺癌女性每年发生对侧乳腺癌的风险约为 0.4%，在 25 年的随访期间持续存在。
Zotero 插件