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剖宫产瘢痕妊娠宫腔镜治疗后女性的后续生育能力:一家三级医院的 5 年随访描述性研究。

Subsequent Fertility in Women Treated for Caesarean Scar Pregnancy With Hysteroscopy: A 5-Year Follow-Up Descriptive Study in a Tertiary Hospital.

机构信息

Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand.

School of Medicine, Nanjing Medical University, Nanjing, China.

出版信息

Front Endocrinol (Lausanne). 2021 May 10;12:659647. doi: 10.3389/fendo.2021.659647. eCollection 2021.

Abstract

OBJECTIVE

The outcomes of subsequent pregnancies and fertility in women with a history of caesarean scar pregnancy have not been well described. In this study, we followed up 149 women with a history of caesarean scar pregnancy and analysed the effect on their fertility.

METHODS

149 women with a history of caesarean scar pregnancy were followed up for five years. Of them, 53 women had unprotected sexual intercourse attempting to become pregnant again. Data including clinical parameters and treatment options at the time of diagnosis of caesarean scar pregnancy, and the outcomes in subsequent pregnancy were collected. In addition, a questionnaire about the menstrual cycle after treatment was voluntarily completed by these women.

RESULTS

Of the 53 women, 46 (84%) women had a subsequent pregnancy, while seven (14%) women did not. There was no association between the clinical parameters in previous caesarean scar pregnancy or treatment and future fertility. From the questionnaire, there was no difference seen in the length of the menstrual cycle and menses between the two groups. However, a higher number of women with light menstrual bleeding were seen in women without a subsequent pregnancy (67%), compared with women who did (28%). In addition, six women (13%) who had a subsequent pregnancy experienced foetus death in the first trimester.

CONCLUSION

We reported that 14% of women with a history of cesarean scar pregnancy did not have a subsequent pregnancy, after unprotected sexual intercourse for more than two years. Light menstrual bleeding after treatment may be associated with this adverse effect. Our findings need to be further investigated with large sample size.

摘要

目的

剖宫产瘢痕妊娠(CSP)病史妇女的后续妊娠结局和生育力尚不清楚。本研究随访了 149 例 CSP 病史妇女,并分析了其对生育力的影响。

方法

随访 149 例 CSP 病史妇女 5 年。其中 53 例无保护性生活尝试再次妊娠。收集包括 CSP 诊断时的临床参数和治疗方案以及后续妊娠结局的数据。此外,这些妇女还自愿完成了关于治疗后月经周期的问卷。

结果

53 例妇女中,46 例(84%)有后续妊娠,7 例(14%)无后续妊娠。既往 CSP 的临床参数或治疗与未来生育力无相关性。从问卷中,两组间的月经周期和经血量无差异。然而,在无后续妊娠的妇女中(67%),更多的妇女出现月经出血减少(28%)。此外,6 例(13%)有后续妊娠的妇女在孕早期发生胎儿死亡。

结论

我们报道,14%的 CSP 病史妇女在无保护性生活超过 2 年后未再次妊娠。治疗后出现经量减少可能与此不良后果有关。我们的研究结果需要进一步大样本量研究证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3143/8142377/daf576dbc698/fendo-12-659647-g001.jpg

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