Division of Cardiology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, Cape Town, ZA.
Hatter Institute for Cardiovascular Research in Africa & CHI, Faculty of Health Sciences, University of Cape Town, South Africa, World Heart Federation, ZA.
Glob Heart. 2021 Apr 19;16(1):22. doi: 10.5334/gh.950.
The emergence of novel coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has presented an unprecedented global challenge for the healthcare community. The ability of SARS-CoV-2 to get transmitted during the asymptomatic phase, and its high infectivity have led to the rapid transmission of COVID-19 beyond geographic regions facilitated by international travel, leading to a pandemic. To guide effective control and interventions, primary data is required urgently, globally, including from low- and middle-income countries where documentation of cardiovascular manifestations and risk factors in people hospitalized with COVID-19 is limited.
This study aims to describe the cardiovascular manifestations and cardiovascular risk factors in patients hospitalized with COVID-19.
We propose to conduct an observational cohort study involving 5000 patients recruited from hospitals in low-, middle- and high-income countries. Eligible adult COVID-19 patients will be recruited from the participating hospitals and followed-up until 30 days post admission. The outcomes will be reported at discharge and includes the need of ICU admission, need of ventilator, death (with cause), major adverse cardiovascular events, neurological outcomes, acute renal failure, and pulmonary outcomes.
Given the enormous burden posed by COVID-19 and the associated severe prognostic implication of CVD involvement, this study will provide useful insights on the risk factors for severe disease, clinical presentation, and outcomes of various cardiovascular manifestations in COVID-19 patients particularly from low and middle income countries from where the data remain scant.
由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的 2019 年新型冠状病毒病（COVID-19）的出现，给医疗保健界带来了前所未有的全球挑战。SARS-CoV-2 在无症状期传播的能力及其高传染性，导致 COVID-19 通过国际旅行在地理区域内迅速传播，引发了大流行。为了指导有效的控制和干预，全球范围内需要包括来自中低收入国家的原始数据，这些国家对因 COVID-19 住院的人群的心血管表现和危险因素的记录有限。
本研究旨在描述因 COVID-19 住院的患者的心血管表现和心血管危险因素。
我们建议进行一项观察性队列研究，纳入来自低、中、高收入国家的 5000 名患者。将从参与医院招募符合条件的成年 COVID-19 患者，并进行随访，直到入院后 30 天。将在出院时报告结果，包括需要 ICU 入院、需要呼吸机、死亡（死因）、主要不良心血管事件、神经学结果、急性肾功能衰竭和肺部结局。
鉴于 COVID-19 带来的巨大负担以及 CVD 参与的相关严重预后意义，这项研究将为严重疾病的危险因素、COVID-19 患者的各种心血管表现的临床表现和结局提供有用的见解，特别是来自数据仍然匮乏的中低收入国家。
