Hua Rong, Liu Mingxi
State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Front Cell Dev Biol. 2021 May 10;9:670599. doi: 10.3389/fcell.2021.670599. eCollection 2021.
Meiosis is a highly conserved and essential process in gametogenesis in sexually reproducing organisms. However, there are substantial sex-specific differences within individual species with respect to meiosis-related chromatin reorganization, recombination, and tolerance for meiotic defects. A wide range of murine models have been developed over the past two decades to study the complex regulatory processes governing mammalian meiosis. The present review article thus provides a comprehensive overview of the knockout mice that have been employed to study meiosis, with a particular focus on gene- and gametogenesis-related sexual dimorphism observed in these model animals. In so doing, we aim to provide a firm foundation for the future study of sex-specific differences in meiosis at the molecular level.
减数分裂是有性生殖生物体配子发生过程中高度保守且必不可少的过程。然而，在减数分裂相关的染色质重组、重组以及对减数分裂缺陷的耐受性方面，单个物种内存在显著的性别特异性差异。在过去二十年中，已经开发了多种小鼠模型来研究控制哺乳动物减数分裂的复杂调控过程。因此，本综述文章全面概述了用于研究减数分裂的基因敲除小鼠，特别关注在这些模型动物中观察到的与基因和配子发生相关的性别二态性。通过这样做，我们旨在为未来在分子水平上研究减数分裂中的性别特异性差异提供坚实的基础。
