Department of Internal Medicine, Ohio State University-Wexner Medical Center, 395 West 12th Avenue, Columbus, OH 43210, USA.
Ohio State University-Wexner Medical Center, 452 West 10th Avenue, Columbus, OH 43210, USA.
Heart Fail Clin. 2019 Oct;15(4):509-517. doi: 10.1016/j.hfc.2019.06.003. Epub 2019 Aug 7.
Metabolic syndrome is an increasingly prevalent constellation of disease processes among the global population. Hypertension and obesity are among the contributing etiologies, and obesity increases the likelihood of hypertensive heart disease by creating a proinflammatory state, as well as increasing sympathetic tone and formation of reactive oxygen species. Hypertensive heart disease is characterized by myocardial fibrosis, which portends higher risk of developing reduced ejection fraction, diastolic dysfunction, ischemia, and arrhythmias, making early diagnosis and treatment essential to the prevention of cardiac events.
代谢综合征是全球人群中日益普遍存在的一组疾病。高血压和肥胖是其中的致病因素,肥胖通过产生促炎状态、增加交感神经张力和形成活性氧来增加患高血压性心脏病的可能性。高血压性心脏病的特征是心肌纤维化,这预示着射血分数降低、舒张功能障碍、缺血和心律失常的风险增加,因此早期诊断和治疗对于预防心脏事件至关重要。