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本文引用的文献

1
Fuzzy-multidimensional deep learning for efficient prediction of patient response to antiretroviral therapy.用于高效预测患者对抗逆转录病毒疗法反应的模糊多维深度学习
Heliyon. 2019 Jul 20;5(7):e02080. doi: 10.1016/j.heliyon.2019.e02080. eCollection 2019 Jul.
2
The HIVdb system for HIV-1 genotypic resistance interpretation.HIVdb 系统用于 HIV-1 基因型耐药性解释。
Intervirology. 2012;55(2):98-101. doi: 10.1159/000331998. Epub 2012 Jan 24.

用于对照实验的经过处理的HIV预后数据集。

Processed HIV prognostic dataset for control experiments.

作者信息

Ekpenyong Moses E, Etebong Philip I, Jackson Tenderwealth C, Udofa Edidiong J

机构信息

Department of Computer Science, University of Uyo, P.M.B. 1017 520003, Uyo, Akwa Ibom State, Nigeria.

Centre for Research and Development, University of Uyo, P.M.B. 1017 520003, Uyo, Akwa Ibom State, Nigeria.

出版信息

Data Brief. 2021 May 14;36:107147. doi: 10.1016/j.dib.2021.107147. eCollection 2021 Jun.

DOI:10.1016/j.dib.2021.107147
PMID:34041323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8142042/
Abstract

This paper provides a control dataset of processed prognostic indicators for analysing drug resistance in patients on antiretroviral therapy (ART). The dataset was locally sourced from health facilities in Akwa Ibom State of Nigeria, West Africa and contains 14 attributes with 1506 unique records filtered from 3168 individual treatment change episodes (TCEs). These attributes include sex, before and follow-up CD4 counts (BCD4, FCD4), before and follow-up viral load (BRNA, FRNA), drug type/combination (DTYPE), before and follow-up body weight (Bwt, Fwt), patient response to ART (PR), and classification targets (C1-C5). Five (5) output membership grades of a fuzzy inference system ranging from very high interaction to no interaction were constructed to model the influence of adverse drug reaction (ADR) and subsequently derive the PR attribute (a non-fuzzy variable). The PR attribute membership clusters derived from a universe of discourse table were then used to label the classification targets as follows: C1=no interaction, C2=very low interaction, C3=low interaction, C4=high interaction, and C5=very high interaction. The classification targets are useful for building classification models and for detecting patients with ADR. This data can be exploited for the development of expert systems, for useful decision support to treatment failure classification [1] and effectual drug regimen prescription.

摘要

本文提供了一个经过处理的预后指标控制数据集,用于分析接受抗逆转录病毒治疗(ART)患者的耐药性。该数据集本地源自西非尼日利亚阿夸伊博姆州的医疗机构,包含14个属性,从3168个个体治疗变化事件(TCE)中筛选出1506条唯一记录。这些属性包括性别、治疗前和治疗后的CD4计数(BCD4、FCD4)、治疗前和治疗后的病毒载量(BRNA、FRNA)、药物类型/组合(DTYPE)、治疗前和治疗后的体重(Bwt、Fwt)、患者对ART的反应(PR)以及分类目标(C1 - C5)。构建了一个模糊推理系统的五个(5)输出隶属度等级,范围从非常高的相互作用到无相互作用,以模拟药物不良反应(ADR)的影响,并随后推导出PR属性(一个非模糊变量)。然后,从论域表中得出的PR属性隶属度聚类用于如下标记分类目标:C1 = 无相互作用,C2 = 非常低的相互作用,C3 = 低相互作用,C4 = 高相互作用,C5 = 非常高的相互作用。这些分类目标对于构建分类模型以及检测有ADR的患者很有用。此数据可用于开发专家系统,为治疗失败分类[1]提供有用的决策支持以及制定有效的药物治疗方案。